Swine CCL2 (MCP-1) Recombinant Protein

Catalog Number:: RP0017S
Availability:: In stock
Application:: Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
100% Homology:: Sus scrofa (pig)

Product Description

Swine CCL2 (catalog RP0017S) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS containing at least 0.1% carrier protein. The protein is ~8.6 kDa, 76 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use. It is commonly used to study chemokine signaling and monocyte/macrophage chemoattraction and migration; typical experimental uses include chemotaxis and cell-migration assays, cell-culture stimulation and dosing studies, ELISA and neutralization assays, receptor-binding studies, flow-cytometry controls, and antibody generation/validation.

Specifications

Amino Acid Sequence	QPDAINSPVT CCYTLTSKKI SMQRLMSYRR VTSSKCPKEA VIFKTIAGKE ICAEPKQKWV QDSISHLDKK NQTPKP (76)
Endotoxin	Naturally endotoxin-free

Properties

Storage Conditions	-20°C
Molecular Weight	8.6 kDa
Purity	>98% as visualized by SDS-PAGE analysis.
Country Of Origin	USA

Background Info

Swine CCL2 (C-C motif chemokine ligand 2, also known as monocyte chemoattractant protein-1, MCP-1) is a pro-inflammatory chemokine that plays an important role in recruitment and activation of monocytes, macrophages, and memory T cells during immune responses in pigs (Sus scrofa domesticus). CCL2 signals primarily through the CCR2 receptor, activating intracellular pathways that promote leukocyte migration, cytokine production, and coordination of innate and adaptive immune responses at sites of infection, inflammation, or tissue injury. In swine health, CCL2 is particularly relevant in respiratory and systemic infectious diseases, including porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza, and bacterial pneumonia, where monocyte and macrophage recruitment to the lungs influences both antiviral defense and inflammatory lung pathology. CCL2 is also involved in inflammatory responses in tissues such as the gut and joints, contributing to immune cell infiltration and tissue remodeling. While CCL2-mediated immune cell trafficking supports pathogen clearance and tissue repair, excessive or prolonged expression can contribute to chronic inflammation and tissue damage. Because pigs are widely used as large-animal models for human infectious, inflammatory, and cardiovascular diseases, characterization of swine CCL2 supports research into chemokine-mediated immune regulation, host-pathogen interactions, and development of anti-inflammatory or immunomodulatory therapies relevant to both veterinary and human medicine.

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