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Equine IL-15 Recombinant Protein
- Catalog Number:
- RP0044E
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Equus caballus (horse)
- Equine IL-15 (catalog RP0044E) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~13.0 kDa, 114 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to horse. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable at least 3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use. It is commonly used in immunology and cell-biology research to study IL-15 signaling and NK-cell and CD8⁺ T-cell proliferation/survival and memory responses; typical experimental uses include cell-culture stimulation and dosing studies, proliferation and cytotoxicity assays, ELISA and neutralization assays, flow-cytometry controls, and antibody generation/validation.
| Amino Acid Sequence | NWQDVISDLK RIEDLIQSIH VDATLYTESD AHPNCKVTAM KCFLLELHVI SHESRNEDIK ETVENLIILA NSSLSSNGNV TESGCKECEE LEEKNIKEFL QSFVHIVQMF INPS (114) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 13.0 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Equine Interleukin-15 (IL-15) is a cytokine that plays an important role in regulating innate and adaptive immune responses in horses (Equus caballus). IL-15 is produced by a variety of cell types, including monocytes, macrophages, dendritic cells, and epithelial cells, in response to infection or inflammatory stimuli. Equine IL-15 signals through a receptor complex composed of IL-15Rα together with the shared IL-2/15Rβ (CD122) and common γ chain (γc), activating intracellular signaling pathways such as JAK-STAT that promote lymphocyte proliferation, survival, and activation. In horses, IL-15 is particularly important for the development, maintenance, and activation of natural killer (NK) cells and memory CD8⁺ T cells, supporting cytotoxic immune responses against infected or abnormal cells. It also contributes to regulation of mucosal and inflammatory immune responses in tissues such as the respiratory and gastrointestinal tracts. In cell culture, recombinant equine IL-15 is commonly used to stimulate proliferation and survival of NK cells and cytotoxic T lymphocytes, maintain memory CD8⁺ T cell populations, and enhance cytotoxic activity in in vitro immune assays. Equine IL-15 is also studied in veterinary and translational research, including investigations of immune responses to equine infectious diseases such as equine herpesvirus and Rhodococcus equi, as well as studies of vaccine responses and immune regulation relevant to both equine health and comparative immunology.
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