Swine IL-15 Recombinant Protein

Catalog Number:: RP0045S
Availability:: In stock
Application:: Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
100% Homology:: Phacochoerus africanus (Common warthog), Sus scrofa (pig)

Product Description

Swine IL-15 (catalog RP0045S) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~13.1 kDa, 114 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology across pig and the common warthog. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable at least 3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use. It is commonly used in immunology and cell-biology research to study IL-15 signaling, NK-cell and CD8⁺ T-cell proliferation/survival and memory responses; typical experimental uses include cell-culture stimulation and dosing studies, proliferation and cytotoxicity assays, ELISA and neutralization assays, flow-cytometry controls, and antibody generation/validation.

Specifications

Amino Acid Sequence	TWQHVISDLK KIEDLIRSIH MDATLYTESD AHPNCKVTAM KCFLLELRVI LQESRNSDIS DTVENLIILA NSSLSSIEYK TESGCKECEE LEEKNINEFL KSFIHIVQMF INPS (114)
Endotoxin	Naturally endotoxin-free

Properties

Storage Conditions	-20°C
Molecular Weight	13.1 kda
Purity	>98% as visualized by SDS-PAGE analysis.
Country Of Origin	USA

Background Info

Swine Interleukin-15 (IL-15) is a cytokine that plays an important role in regulating innate and adaptive immune responses in pigs (Sus scrofa). IL-15 is produced by a variety of cell types, including monocytes, macrophages, dendritic cells, and epithelial cells, in response to infection or inflammatory stimuli. Swine IL-15 signals through a receptor complex composed of IL-15Rα together with the shared IL-2/15Rβ (CD122) and common γ chain (γc), activating intracellular signaling pathways such as JAK-STAT that promote lymphocyte proliferation, survival, and activation. In pigs, IL-15 is particularly important for the development, maintenance, and activation of natural killer (NK) cells and memory CD8⁺ T cells, supporting cytotoxic immune responses against infected or abnormal cells. It also contributes to regulation of mucosal immunity and inflammatory responses in tissues such as the respiratory and gastrointestinal tracts. In cell culture, recombinant swine IL-15 is commonly used to stimulate proliferation and survival of NK cells and cytotoxic T lymphocytes, maintain memory CD8⁺ T cell populations, and enhance cytotoxic activity in in vitro immune assays. Swine IL-15 is widely studied in veterinary and translational research, including investigations of immune responses to important swine pathogens such as porcine reproductive and respiratory syndrome virus (PRRSV), African swine fever virus (ASFV), and Salmonella spp., where IL-15-mediated activation of cytotoxic lymphocytes helps researchers evaluate vaccine candidates and antiviral immune responses.

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