Bovine IL-17A Recombinant Protein

Catalog Number:: RP0056B
Availability:: In stock
Application:: Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
100% Homology:: Bos indicus (zebu), Bos javanicus (banteng), Bos taurus (cattle)

Bovine IL-17A (catalog RP0056B) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~17.4 kDa, 132 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology across cattle, zebu, and banteng. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable at least 3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use. It is commonly used in immunology and cell-biology research to study IL-17 signaling, neutrophil recruitment and activation, mucosal immunity and Th17 responses; typical experimental uses include cell-culture stimulation and dosing studies, chemotaxis and neutrophil-activation assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation.

Amino Acid Sequence	KAGVIIPQSP GCPPTEDKNF PQHVRVNLNI VNRSTNSRRP TDYHKRSTSP WTLHRNEDPE RYPSVIWEAK CSHSGCINAE GKVDHHMNSV TIQQEILVLR RESQHCPHSF RLEKMLVAVG CTCVTPIVRH LA (132)
Endotoxin	Naturally endotoxin-free

Storage Conditions	-20°C
Molecular Weight	15.0 kDa
Purity	>98% as visualized by SDS-PAGE analysis.
Country Of Origin	USA

Bovine IL-17A (Interleukin-17A) is a pro-inflammatory cytokine belonging to the IL-17 family that plays a critical role in host defense and inflammatory responses in cattle (Bos taurus). IL-17A is produced primarily by Th17 cells, as well as by γδ T cells-which are abundant in ruminants-and other innate lymphoid cell populations in response to microbial infection and inflammatory stimulation. It acts on epithelial, endothelial, and stromal cells to induce expression of pro-inflammatory cytokines, chemokines (such as CXCL8), and antimicrobial peptides, thereby promoting neutrophil recruitment and enhancing mucosal and barrier immunity. In healthy cattle, basal IL-17A expression is generally low, but levels increase during bacterial and fungal infections, mastitis, respiratory disease, enteric infections, and parasitic challenges. IL-17A has been implicated in immune responses to pathogens such as Mycobacterium bovis, bovine respiratory disease complex agents, and gastrointestinal nematodes. In veterinary and agricultural research, bovine IL-17A serves as an important biomarker of Th17-mediated immunity and neutrophilic inflammation, providing insight into host-pathogen interactions, vaccine responses, and inflammatory disease mechanisms in cattle.

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