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Equine CXCL10 (IP-10) Recombinant Protein
- Catalog Number:
- RP0058E
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Equus caballus (horse), Equus przewalskii (Przewalski's horse)
- Equine CXCL10 (alias IP-10, interferon-gamma-inducible protein 10) (catalog RP0058E) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~9.4 kDa, 83 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology across horse and Przewalski's horse. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable at least 3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use. It is commonly used in immunology and cell-biology research to study chemokine signaling and leukocyte chemoattraction/migration (particularly CXCR3⁺ T cells and NK cells), inflammation and immune-cell trafficking; typical experimental uses include chemotaxis and cell-migration assays, receptor-binding and signaling studies, cell-culture stimulation and dosing, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation.
| Amino Acid Sequence | IPLSRTARCT CINISDRPIP PRSLEKLEMI PASQSCQRVE IIATMKKNGE KRCLNPESKT VKNLLKAISK QRSKRSPRTL REV (83) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 9.4 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Equine CXCL10 (C-X-C motif chemokine ligand 10), also known as IP-10 (Interferon gamma-induced protein 10), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL9 (MIG) and CXCL11 (I-TAC) that regulate T-cell recruitment during antiviral and inflammatory immune responses. In horses (Equus caballus), CXCL10 is produced by macrophages, dendritic cells, epithelial cells, endothelial cells, and fibroblasts in response to interferon-γ (IFN-γ), viral infection, or inflammatory cytokines. CXCL10 signals primarily through the chemokine receptor CXCR3, which is expressed on activated T lymphocytes, natural killer (NK) cells, and other immune cells, promoting chemotaxis and activation of these immune cells at sites of infection or inflammation. In equine health, CXCL10 contributes to immune responses against viral and bacterial pathogens, including equine herpesvirus (EHV) infections and equine influenza virus, where recruitment of Th1-type T cells is important for antiviral immunity. Horses are also used as animal models for respiratory viral diseases, and CXCL10-mediated recruitment of CXCR3⁺ T cells in the respiratory tract has been studied to better understand interferon-driven immune responses, airway inflammation, and host-pathogen interactions relevant to both veterinary and comparative respiratory disease research.
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