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Bovine VEGF-A Recombinant Protein
- Catalog Number:
- RP0072B
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Bison bison bison (American buffalo), Bos taurus (cattle), Bubalus bubalis (water buffalo), Bubalus kerabau (carabao)
- Bovine VEGF-A (alias VEGF-A, vascular endothelial growth factor A) (catalog RP0072B) is a yeast-derived growth factor supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~19.2 kDa, 164 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology across several bovine species (cattle, American buffalo, water buffalo, and carabao). Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable at least 3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. Kingfisher Biotech products are supplied for research use and are not intended for medicinal, diagnostic, or therapeutic use. It is commonly used to study angiogenesis, endothelial-cell proliferation, migration, vascular permeability and signaling through VEGF receptors; typical experimental uses include endothelial cell culture stimulation and proliferation/tube-formation assays, receptor-binding and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation.
| Amino Acid Sequence | APMAEGGQKP HEVVKFMDVY QRSFCRPIET LVDIFQEYPD EIEFIFKPSC VPLMRCGGCC NDESLECVPT EEFNITMQIM RIKPHQSQHI GEMSFLQHNK CECRPKKDKA RQENPCGPCS ERRKHLFVQD PQTCKCSCKN TDSRCKARQL ELNERTCRCD KPRR (164) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 19.2 kda |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Bovine Vascular Endothelial Growth Factor A (VEGF-A) is a member of the vascular endothelial growth factor (VEGF) family, which includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, and placental growth factor (PlGF)-key regulators of angiogenesis and vascular development. In cattle (Bos taurus), VEGF-A is produced by multiple cell types including endothelial cells, macrophages, fibroblasts, epithelial cells, and trophoblast cells, particularly in response to hypoxia, inflammation, and tissue injury. VEGF-A exerts its biological effects mainly by binding to VEGF receptor-1 (VEGFR-1/Flt-1) and VEGF receptor-2 (VEGFR-2/KDR) on endothelial cells, activating intracellular signaling pathways such as MAPK/ERK, PI3K/AKT, and PLCγ, which promote endothelial cell proliferation, migration, vascular permeability, and formation of new blood vessels. In bovine physiology, VEGF-A plays critical roles in placental vascular development, reproductive function, mammary gland development, and tissue repair. It is particularly important during pregnancy and placentation, where VEGF-mediated angiogenesis supports maternal-fetal blood supply and nutrient exchange. VEGF-A is also involved in wound healing and inflammatory responses, contributing to vascular remodeling and tissue regeneration. Because angiogenesis is essential for reproductive efficiency, mammary gland function, and tissue repair in cattle, bovine VEGF-A is widely studied in reproductive biology, placental development, vascular biology, and livestock health research.
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