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Bovine IL-1 alpha Recombinant Protein
- Catalog Number:
- RP0097B
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Bison bison bison (American buffalo), Bos indicus (zebu), Bos javanicus (banteng), Bos taurus (cattle)
- Bovine IL-1α (catalog RP0097B) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~17.1 kDa, 149 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology across several bovine species (cattle, zebu, banteng, and American buffalo). Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable at least 3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use. It is commonly used to study IL-1α signaling, inflammation and innate immune responses; typical experimental uses include cell-culture stimulation and dosing studies, cytokine and inflammasome assays, ELISA and neutralization assays, receptor-binding and signaling studies, flow-cytometry and Western blot controls, and antibody generation/validation.
| Amino Acid Sequence | SNVKYNFMRV IHQECILNDA LNQSIIRDMS GPYLTATTLN NLEEAVKFDM VAYVSEEDSQ LPVTLRISKT QLFVSAQNED EPVLLKEMPE TPKIIKDETN LLFFWEKHGS MDYFKSVAHP KLFIATKQEK LVHMASGPPS ITDFQILEK (149) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 17.1 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Bovine Interleukin-1 Alpha (IL-1α) is a pro-inflammatory cytokine belonging to the IL-1 family, which includes IL-1α, IL-1β, and the IL-1 receptor antagonist (IL-1Ra), and plays a central role in initiating and amplifying innate immune responses in cattle (Bos taurus). IL-1α is constitutively expressed in epithelial and barrier tissues and can function as an intracellular alarmin that is released upon cell injury or necrosis, triggering rapid inflammatory signaling. It binds to the IL-1 receptor type 1 (IL-1R1), activating NF-κB and MAPK pathways that promote leukocyte recruitment, endothelial activation, fever, and production of additional pro-inflammatory mediators. In bovine health, IL-1α is particularly relevant in inflammatory conditions such as mastitis, bovine respiratory disease (BRD), metritis, enteric infections, and lameness-associated tissue injury, where it contributes to early neutrophil infiltration and local inflammatory amplification. While essential for pathogen defense and tissue repair, excessive IL-1α signaling can contribute to tissue damage and reduced productivity. As an early mediator of sterile and infectious inflammation, bovine IL-1α serves as a biomarker of tissue injury and innate immune activation. In veterinary and translational research, characterization of bovine IL-1α supports studies of inflammasome-independent inflammatory pathways, host-pathogen interactions, and development of targeted anti-inflammatory or immunomodulatory strategies to improve cattle health, welfare, and disease resilience.
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