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Feline IL-1 beta Recombinant Protein
- Catalog Number:
- RP0098F
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Acinonyx jubatus (cheetah), Felis catus (domestic cat), Leopardus geoffroyi (Geoffroy's cat), Lynx canadensis (Canada lynx), Lynx pardinus (Spanish lynx), Lynx rufus (bobcat), Panthera uncia (snow leopard), Prionailurus bengalensis (leopard cat), Prionailurus viverrinus (fishing cat)
- Feline IL-1β (catalog RP0098F) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~17.4 kDa, 152 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology across several felids: domestic cat, cheetah, Geoffroy's cat, Canada lynx, Spanish lynx, bobcat, snow leopard, leopard cat, and fishing cat. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable at least 3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use. It is commonly used to study IL-1β signaling, inflammation, inflammasome/pyroptosis and innate immune responses; typical experimental uses include cell-culture stimulation and dosing studies, cytokine and inflammasome assays, ELISA and neutralization assays, receptor-binding and signaling studies, flow-cytometry and Western blot controls, and antibody generation/validation.
| Amino Acid Sequence | AAIQSQDYTF RDISQKSLVL SGSYELRALH LNGQNMNQQV VFRMSFVHGE ENSKKIPVVL CIKKNNLYLS CVMKDGKPTL QLEMLDPKVY PKKKMEKRFV FNKTEIKGNV EFESSQFPNW YISTSQAEEM PVFLGNTKGG QDITDFIMES AS (152) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 17.4 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Feline Interleukin-1 Beta (IL-1β) is a potent pro-inflammatory cytokine produced primarily by activated macrophages, monocytes, and dendritic cells in cats (Felis catus) following recognition of pathogens or tissue damage. Synthesized as an inactive precursor (pro-IL-1β), it is cleaved into its active form by caspase-1 within the inflammasome complex and subsequently signals through the IL-1 receptor (IL-1R1), activating NF-κB and MAPK pathways that promote fever, leukocyte recruitment, acute-phase protein production, and amplification of inflammatory responses. In feline health, IL-1β plays a central role in inflammatory and infectious diseases including feline infectious peritonitis (FIP), chronic gingivostomatitis, inflammatory bowel disease, osteoarthritis, and bacterial or viral respiratory infections, where dysregulated IL-1β production can contribute to tissue damage and chronic inflammation. As a biomarker, IL-1β reflects innate immune activation and disease severity in clinical settings. In translational research, cats serve as valuable natural models for human inflammatory disorders, coronavirus-associated immunopathology (FIP), chronic oral inflammatory disease, and osteoarthritis, and characterization of feline IL-1β supports studies of inflammasome activation, cytokine-driven pathology, and development of targeted anti-inflammatory therapies relevant to both veterinary and human medicine.
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