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Feline IL-8 Recombinant Protein
- Catalog Number:
- RP0108F
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Felis catus (domestic cat)
- Feline IL-8 (alias CXCL8, interleukin-8) (catalog RP0108F) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~8.9 kDa, 79 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to domestic cat. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable at least 3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use. It is commonly used to study chemokine signaling, neutrophil and leukocyte chemoattraction/activation, and inflammation; typical experimental uses include chemotaxis and cell-migration assays, cell-culture stimulation and dosing studies, ELISA and neutralization assays, receptor-binding and signaling studies, flow-cytometry and Western blot controls, and antibody generation/validation.
| Amino Acid Sequence | AVLSRISSEL RCQCIKTHST PFNPKLIKEL TVIDSGPHCE NSEIIVKLVN GKEVCLDPKQ KWVQKVVEIF LKKAEKQNA (79) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 8.9kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Feline Interleukin-8 (IL-8), also known as CXCL8, is a potent pro-inflammatory chemokine that plays a central role in innate immune responses in cats (Felis catus) by promoting neutrophil chemotaxis, activation, and migration to sites of infection or tissue injury. Produced by macrophages, epithelial cells, endothelial cells, and fibroblasts in response to microbial stimuli and inflammatory cytokines, feline IL-8 signals primarily through CXCR1 and CXCR2 receptors to activate intracellular pathways that drive leukocyte recruitment and amplification of acute inflammation. Elevated IL-8 expression is associated with numerous feline diseases, including feline infectious peritonitis (FIP), chronic gingivostomatitis, upper and lower respiratory infections, inflammatory bowel disease, and bacterial pneumonias, where excessive neutrophilic infiltration contributes to tissue pathology and disease severity. As a clinical biomarker, IL-8 supports assessment of inflammatory status and therapeutic response in veterinary medicine. Importantly, cats serve as valuable spontaneous animal models for human neutrophil-driven and chronic inflammatory diseases, and characterization of feline IL-8 enhances translational research in mucosal immunology, chronic oral inflammation, asthma-like airway disease, inflammatory bowel disease, and coronavirus-associated immunopathology. Because many feline conditions naturally mirror human inflammatory disorders, studying IL-8 signaling and regulation in cats provides insight into chemokine-mediated tissue damage, immune cell trafficking, and potential therapeutic strategies targeting CXCL8/CXCR pathways in both veterinary and human medicine.
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