Swine IL-17A Recombinant Protein

Catalog Number:: RP0128S
Availability:: In stock
Application:: Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
100% Homology:: Phacochoerus africanus (Common warthog), Sus scrofa (pig)

Swine IL-17A (catalog RP0128S) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~14.9 kDa, 130 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig and the common warthog. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use. It is commonly used to study IL-17 signaling, neutrophil recruitment and activation, mucosal immunity and Th17 responses; typical experimental uses include cell-culture stimulation and dosing studies, chemotaxis and neutrophil-activation assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation.

Amino Acid Sequence	GIMIPQSPGC PKTEDKNFPQ HVRVNLNILN RSTPARRPSD YSKRSTSPWT LQRNEDPERY PSVIWEAKCS HSGCINAEGK EDHHMNSVPI QQEILVLRRE PRHCPNSFRL EKVMVTVGCT CVTPIVRHIS (130)
Endotoxin	Naturally endotoxin-free

Storage Conditions	-20°C
Molecular Weight	14.9 kDa
Purity	>98% as visualized by SDS-PAGE analysis.
Country Of Origin	USA

Swine IL-17A (Interleukin-17A) is a pro-inflammatory cytokine belonging to the IL-17 family that plays a critical role in host defense and inflammatory responses in pigs (Sus scrofa). IL-17A is produced primarily by Th17 CD4⁺ T cells, as well as by γδ T cells-which are abundant in swine-and other innate lymphoid cell populations in response to microbial infection and immune stimulation. It acts on epithelial, endothelial, and stromal cells to induce expression of pro-inflammatory cytokines (e.g., IL-6, TNF-α), chemokines (such as CXCL8), and antimicrobial peptides, thereby promoting neutrophil recruitment and enhancing mucosal barrier immunity in respiratory and gastrointestinal tissues. In healthy pigs, basal IL-17A expression is generally low, but levels increase during bacterial and fungal infections, enteric disease, respiratory inflammation, and parasitic challenge. IL-17A has been implicated in immune responses to pathogens such as porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus, Actinobacillus pleuropneumoniae, and enteric bacteria. In veterinary and translational research, swine IL-17A serves as an important biomarker of Th17-mediated immune activation and neutrophilic inflammation, providing insight into host-pathogen interactions, vaccine-induced immunity, and inflammatory disease mechanisms in both agricultural and biomedical research contexts.

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