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Swine IL-6 Recombinant Protein
- Catalog Number:
- RP0138S
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Sus scrofa (pig)
- Swine IL-6 (catalog RP0138S) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~20.9 kDa, 183 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable at least 3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use. It is commonly used to study IL-6 signaling, acute-phase and inflammatory responses, and B-cell differentiation; typical experimental uses include cell-culture stimulation and dosing studies, proliferation/differentiation assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation.
| Amino Acid Sequence | GRLEEDAKGD ATSDKMLFTS PDKTEELIKY ILGKISAMRK EMCEKYEKCE NSKEVLAENN LNLPKMAEKD GCFQSGFNQE TCLMRITTGL VEFQIYLDYL QKEYESNKGN VEAVQISTKA LIQTLRQKGK NPDKATTPNP TTNAGLLDKL QSQNEWMKNT KIILILRSLE DFLQFSLRAI RIM (183) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 20.9 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Swine Interleukin-6 (IL-6) is a multifunctional pro-inflammatory cytokine and a central member of the IL-6 cytokine family-including IL-6, IL-11, IL-27, IL-31, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), and cardiotrophin-like cytokine factor 1 (CLCF1)-which signal through receptor complexes containing the shared gp130 subunit to activate JAK/STAT and MAPK pathways. In pigs (Sus scrofa domesticus), IL-6 is rapidly produced by macrophages, monocytes, endothelial cells, and epithelial cells in response to infection, tissue injury, and stress, where it regulates acute-phase protein synthesis (including C-reactive protein, haptoglobin, and serum amyloid A), fever, leukocyte activation, and B- and T-cell differentiation. Elevated IL-6 levels are associated with economically significant diseases such as porcine reproductive and respiratory syndrome (PRRS), swine influenza, African swine fever, bacterial sepsis, enteric infections, and post-weaning multisystemic wasting syndrome, where dysregulated IL-6 responses can contribute to systemic inflammation and reduced growth performance. As both a biomarker of immune activation and a mediator of disease severity, swine IL-6 is widely used in herd health monitoring, vaccine evaluation, and immunopathogenesis studies. In translational research, pigs serve as valuable large-animal models due to physiological and immunological similarities to humans, and characterization of swine IL-6 and related family members supports studies in infectious disease, sepsis, trauma, metabolic disorders, and immunomodulatory therapeutic development.
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