Multi-species (Chicken, Duck, Turkey) IGF-2 Recombinant Protein

Catalog Number:: RP0151CT
Application:: Cell Culture, Control, ELISA, ELISpot Control, Western Blot Control
100% Homology:: Acanthisitta chloris (rifleman), Amazona aestiva (blue-fronted amazon), Anas platyrhynchos (mallard), Aptenodytes forsteri (emperor penguin), Balearica regulorum gibbericeps (East African grey crowned-crane), Calidris pugnax (ruff), Calypte anna (Anna's hummingbird), Chaetura pelagica (chimney swift), Charadrius vociferus (killdeer), Colius striatus (speckled mousebird), Columba livia (rock pigeon), Corvus brachyrhynchos (American crow), Coturnix japonica (Japanese quail), Cuculus canorus (common cuckoo), Falco cherrug (Saker falcon), Falco peregrinus (peregrine falcon), Gallus gallus (chicken), Geospiza fortis (medium ground-finch), Haliaeetus leucocephalus (bald eagle), Herpetotheres cachinnans (Laughing Falcon), Leiothrix lutea (red-billed leiothrix), Lepidothrix coronata (blue-crowned manakin), Manacus vitellinus (golden-collared manakin), Meleagris gallopavo (turkey), Melopsittacus undulatus (budgerigar), Merops nubicus (carmine bee-eater), Mesitornis unicolor (brown roatelo), Nestor notabilis (Kea), Nipponia nippon (crested ibis), Piaya cayana (squirrel cuckoo), Picoides pubescens (downy woodpecker), Piprites chloris (white-winged piprites), Pseudopodoces humilis (Tibetan ground-tit), Ptilonorhynchus violaceus (satin bowerbird), Pygoscelis adeliae (Adelie penguin), Semnornis frantzii (Prong-billed barbet), Serinus canaria (common canary), Sinosuthora webbiana (Vinous-throated Parrotbill), Sturnus vulgaris (common starling), Thalassarche chlororhynchos (Atlantic yellow-nosed albatross), Tinamus guttatus (white-throated tinamou), Trogon melanurus (black-tailed trogon), Zonotrichia albicollis (white-throated sparrow)

Product Description

IGF-2 (multi-species: chicken, duck, turkey) (catalog RP0151CT) is a yeast-derived growth factor supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~7.5 kDa, 67 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology across chicken, mallard, turkey and numerous other avian species. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use. It is commonly used to study IGF-2 signaling and growth-factor biology (cell proliferation, metabolic signaling and receptor interactions); typical experimental uses include cell-culture stimulation and dosing studies, proliferation/differentiation assays, receptor-binding and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation.

Properties/Specifications

Amino Acid Sequence	YGTAETLCGG ELVDTLQFVC GDRGFYFSRP VGRNNRRINR GIVEECCFRS CDLALLETYC AKSVKSE (67)
Endotoxin	Naturally endotoxin-free
Form	Lyophilized
Storage Conditions	-20°C
Molecular Weight	7.5 kDa
Purity	>98% as visualized by SDS-PAGE analysis.
Affinity Tag	None
aminoAcids	67
Carrier Protein	None
Expression System	Yeast
Form	Lyophilized
Country Of Origin	USA

Avian Insulin-like Growth Factor 2 (IGF-2) is a peptide growth factor involved in regulating embryonic development, tissue growth, and metabolic processes in birds including chicken (Gallus gallus), duck (Anas platyrhynchos), and turkey (Meleagris gallopavo). The IGF-2 protein is identical at the amino acid level among these species, reflecting strong evolutionary conservation and its essential role in avian development and physiology. IGF-2 is expressed in multiple tissues, particularly during embryonic development, where it promotes cell proliferation, differentiation, and survival. Avian IGF-2 primarily binds to the insulin-like growth factor 1 receptor (IGF1R) and can also interact with the insulin receptor, activating intracellular signaling pathways including PI3K–AKT and MAPK that regulate gene expression, cell growth, and metabolism. In chickens, ducks, and turkeys, IGF-2 contributes to embryonic growth, skeletal and muscle development, and regulation of metabolic processes during early life stages. Due to these functions and its conserved structure, IGF-2 is widely studied in avian developmental biology and poultry science, where it is associated with growth regulation, muscle development, and traits relevant to poultry production and health.