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Swine IL-22 Recombinant Protein
- Catalog Number:
- RP0262S
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Phacochoerus africanus (Common warthog), Sus scrofa (pig)
- Swine IL-22 (catalog RP0262S) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~18.0 kDa, 156 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with amino-acid homology to pig and the common warthog (sequence annotated [Gln51/52]). Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use. It is commonly used to study IL-22 signaling, epithelial and barrier biology, mucosal immunity, tissue repair and antimicrobial peptide induction; typical experimental uses include cell-culture stimulation and dosing studies, epithelial-cell functional assays, cytokine signaling and receptor-binding studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation.
| Amino Acid Sequence | VPITHHCKLD QSNFQQPYIT NRTFTLAQEA SLADNNTDVR LIGNNLFQGV NMRERCYLVK QVLNFTLEEV LFPNSDRFHP YMQEVASFLD SLSKKLSQCR IKGDDQHIQR NVNNFKDTVK KLGESGEIKV IGELYLLFMA LKNECTLPGH SWKMDN (156) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 18.0 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Swine IL-22 (Interleukin-22) is a member of the IL-10 cytokine family that plays a key role in mucosal immunity and epithelial barrier protection in pigs (Sus scrofa). IL-22 is produced primarily by activated CD4⁺ T cells, including Th17- and Th22-like subsets, as well as by γδ T cells and innate lymphoid cells (ILC3s), in response to microbial infection and inflammatory stimulation. It signals through the IL-22 receptor complex (IL-22R1 and IL-10R2), expressed mainly on epithelial and stromal cells, activating downstream JAK/STAT pathways-particularly STAT3-to induce antimicrobial peptide production, enhance chemokine expression, promote epithelial cell proliferation, and support tissue repair. In healthy swine, basal IL-22 expression is generally low but increases during bacterial, viral, and parasitic infections, particularly at mucosal surfaces of the gastrointestinal and respiratory tracts. Swine IL-22 has been implicated in immune responses to enteric pathogens such as Escherichia coli and Salmonella, as well as respiratory pathogens including porcine reproductive and respiratory syndrome virus (PRRSV) and swine influenza virus. In veterinary and translational research, swine IL-22 serves as a biomarker of mucosal immune activation and epithelial defense and is studied in the context of host-pathogen interactions, vaccine efficacy, and maintenance of barrier integrity in both agricultural and biomedical disease models.
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