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Rabbit IL-4 (Yeast-derived Recombinant Protein) - 100 micrograms

RP0264U-100
$900.00
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Bulk quantities of Rabbit IL-4 protein are available.
Please contact us for pricing.

Rabbit IL-4 Specifications

Molecular Weight (calculated) - 14.2kDa

Amino Acid Sequence - GRRGDIILPE VIKTLNILTE RKTPCTKLMI ADALAVPKNT TEREAVCRAA TALRQFYLHH KVSWCFKEHG ELGDLRLLRG LDRNLCSMAK LSNCPGKEAR QTTLEDFLDR LKTAMQEKYS KRQS (124)

Gene ID - 100302454

Homology Across Species
Oryctolagus cuniculus (rabbit) IL-4 – 100%
More - https://blast.ncbi.nlm.nih.gov/

Endotoxin - Naturally endotoxin-free

Applications

Cell Culture, ELISA Standard, Western Blot Control

IL-4 Background

Interleukin-4 (IL-4) induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4. IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. IL-4 induces B-cell class switching to IgE, and up-regulates MHC class II production. Overproduction of IL-4 is associated with allergies.

Alternate Names - IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4, interleukin 4

Rabbit IL-4 (Yeast-derived Recombinant Protein) - 100 micrograms
Catalog No.:
RP0264U-100
Quantity:
100 ug
Source:
The Rabbit IL-4 recombinant protein was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
MW:
The Rabbit IL-4 recombinant protein has a predicted molecular weight of 14.2 kDa.
Protein Sequence:
GRRGDIILPE VIKTLNILTE RKTPCTKLMI ADALAVPKNT TEREAVCRAA TALRQFYLHH KVSWCFKEHG ELGDLRLLRG LDRNLCSMAK LSNCPGKEAR QTTLEDFLDR LKTAMQEKYS KRQS (124)
Country of Origin:
USA
Applications:
The Rabbit IL-4 endotoxin-free recombinant protein can be used in cell culture, as an IL-4 ELISA Standard, and as a Western Blot Control.

28222511

Evaluation of a DNA Aβ42 Vaccine in Aged NZW Rabbits: Antibody Kinetics and Immune Profile after Intradermal Immunization with Full-Length DNA Aβ42 Trimer.

Lambracht-Washington D, Fu M, Wight-Carter M, Riegel M, Rosenberg RN.

J Alzheimers Dis. 2017;57(1):97-112. doi: 10.3233/JAD-160947.

Applications: Determine frequencies of cytokine secreting cells by ELISPOT for rabbit IFN gamma, IL-17A, and IL-4.

Abstract
A pathological hallmark of Alzheimer's disease (AD) are amyloid plaques in the brain consisting of aggregated amyloid-β 42 peptide (Aβ42) derived from cellular amyloid-β protein precursor (AβPP). Based on successful experiments in mouse AD models, active immunization with Aβ42 peptide and passive immunizations with anti-Aβ42 antibodies were started in clinical trials. Active Aβ42 peptide immunization in humans had led to an inflammatory autoimmune response, and the trial was stopped. Passive immunizations had shown some effects in slowing AD pathology. Active DNA Aβ42 immunizations administered with the gene gun into the skin elicits a different immune response and is non-inflammatory. While in rodents, good responses had been found for this type of immunization, positive results in larger mammals are missing. We present here results from sixteen New Zealand White Rabbits, which underwent intradermal DNA Aβ42 immunization via gene gun. The humoral immune response was analyzed from blood throughout the study, and cellular immune responses were determined from spleens at the end of the study. A good anti-Aβ antibody response was found in the rabbit model. The T cell response after re-stimulation in cell culture showed no IFNγ producing cells when ELISPOT assays were analyzed from PBMC, but low numbers of IFNγ and IL-17 producing cells were found in ELISPOTS from spleens (both 5 immunizations). Brains from immunized rabbits showed no signs of encephalitis. Based on these results, DNA Aβ42 immunization is highly likely to be safe and effective to test in a possible clinical AD prevention trial in patients.


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