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Swine IL-17F Recombinant Protein
- Catalog Number:
- RP0291S
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Phacochoerus africanus (Common warthog), Sus scrofa (pig)
- Swine IL-17F (catalog RP0291S) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~15.5 kDa, 138 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig and the common warthog. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-17 signaling, neutrophil recruitment and activation, mucosal immunity and Th17 responses; typical experimental uses include cell-culture stimulation and dosing studies, chemotaxis and neutrophil-activation assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation.
| Amino Acid Sequence | ARKILKPGDP ALCPPLEDHS VRVDIRILSQ NQGVPLSHDF QNRSSSPWDY NITRDPHRFP SEIAEARCRH TGCINAQGQE DSSMNSVPIQ QEFLVLRREP QGCSRSFRLE KVRVTVGCTC VTPMVRYVRG LRAAGQLG (138) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 15.5 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Swine IL-17F (Interleukin-17F) is a pro-inflammatory cytokine of the IL-17 family that plays a key role in host defense and inflammatory regulation in pigs (Sus scrofa). IL-17F is produced primarily by Th17 CD4⁺ T cells, as well as by γδ T cells-which are prominent in swine-and other innate lymphoid populations following microbial infection or immune stimulation. It signals through the IL-17 receptor complex (IL-17RA/IL-17RC) to induce expression of pro-inflammatory cytokines (e.g., IL-6, TNF-α), chemokines such as CXCL8, and antimicrobial peptides, thereby promoting neutrophil recruitment and enhancing mucosal barrier immunity in the respiratory and gastrointestinal tracts. IL-17F frequently acts synergistically with IL-17A to amplify Th17-driven inflammatory responses. In healthy pigs, basal IL-17F expression is generally low, but levels increase during bacterial and fungal infections, parasitic infestations, enteric inflammation, and respiratory disease. Swine IL-17F has been implicated in immune responses to pathogens such as porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus, Actinobacillus pleuropneumoniae, and enterotoxigenic Escherichia coli. In veterinary and translational research, IL-17F serves as a biomarker of Th17-mediated immune activation and neutrophilic inflammation, providing insight into host-pathogen interactions, mucosal immunity, and vaccine-induced immune responses in porcine health and biomedical models.
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