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Canine IL-24 Recombinant Protein
- Catalog Number:
- RP0293D
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Canis lupus familiaris (dog)
- Canine IL-24 (catalog RP0293D) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~18.2 kDa, 155 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to dog. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-24 signaling, epithelial and tumor biology, wound healing and immune regulation; typical experimental uses include cell-culture stimulation and dosing studies, proliferation/apoptosis and signaling assays, ELISA and neutralization assays, receptor-binding and signaling studies, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | QEFRFGPCRV QGVALRELRE AFWTVKDTVQ AKDNITSVRL LRKEVLQDVS DAESCYLIRA LLKFYLNTVF KNYLDEAADV RIRRSFSTLA NNFFVIASKL QPSQEDEMFS ISESARRRFL LFQRAFKQLD IQAAQTKAFG EVDILLTWME KFYEF (155) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 18.2 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Canine interleukin-24 (cIL-24) is a member of the IL-10 cytokine family-which includes IL-10, IL-19, IL-20, IL-22, and IL-26-and is homologous to human IL-24 (MDA-7), functioning in immune regulation, epithelial biology, inflammation control, and tumor suppression through IL-20 receptor-mediated JAK/STAT signaling pathways. Within animal health, cIL-24 is particularly relevant in veterinary oncology, where it is being explored for tumor-selective pro-apoptotic, anti-angiogenic, and immune-modulating effects in canine melanoma, lymphoma, mast cell tumors, and osteosarcoma-diseases that closely parallel human melanoma, non-Hodgkin lymphoma, breast cancer, colorectal cancer, lung cancer, pancreatic cancer, and osteosarcoma in their molecular drivers and tumor microenvironment. In coordination with other IL-10 family members such as IL-22 (epithelial barrier protection), IL-20 (skin and tissue inflammation), and IL-10 (anti-inflammatory regulation), cIL-24 may also contribute to immune balance in chronic inflammatory and immune-mediated disorders in dogs, including atopic dermatitis and inflammatory bowel disease, which resemble human psoriasis, Crohn's disease, ulcerative colitis, rheumatoid arthritis, and atopic dermatitis. Because spontaneous cancers and inflammatory diseases in dogs arise naturally in immunocompetent animals, canine IL-24 and related IL-10 family cytokines support both improved veterinary therapeutic development and highly relevant translational animal models that advance comparative immunology and immuno-oncology research.
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