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Feline IL-1 alpha Recombinant Protein
- Catalog Number:
- RP0295F
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Felis catus (domestic cat)
- Feline IL-1α (catalog RP0295F) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~18.0 kDa, 158 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to domestic cat. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-1α signaling, inflammation and innate immune responses; typical experimental uses include cell-culture stimulation and dosing studies, cytokine and inflammasome assays, ELISA and neutralization assays, receptor-binding and signaling studies, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | SVAPNFYSSE KYNYQKIIKS QFILNDNLSQ SVIRKAGGKY LAAAALQNLD DAVKFDMGAY TSKEDSKLPV TLRISKTRLF VSAQNEDEPV LLKEMPETPK TIRDETNLLF FWERHGSKNY FKSVAHPKLF IATQEEQLVH MARGLPSVTD FQILETQS (158) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 18.0 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Feline Interleukin-1 Alpha (IL-1α) is a pro-inflammatory cytokine belonging to the IL-1 family, which includes IL-1α, IL-1β, and the IL-1 receptor antagonist (IL-1Ra), and plays a central role in initiating and amplifying innate immune responses in cats (Felis catus). Unlike IL-1β, IL-1α is constitutively expressed in epithelial and other barrier tissues and can function as both a membrane-bound and intracellular alarmin released upon cell injury or necrosis. IL-1α signals through the IL-1 receptor type 1 (IL-1R1), activating NF-κB and MAPK pathways that drive leukocyte recruitment, fever, endothelial activation, and production of additional pro-inflammatory mediators. In feline health, IL-1α is particularly relevant in inflammatory skin diseases, chronic gingivostomatitis, inflammatory bowel disease, respiratory infections, and osteoarthritis, where it contributes to local tissue inflammation and immune cell infiltration. Dysregulated IL-1α signaling may exacerbate chronic inflammatory conditions and tissue damage. As both an early mediator of sterile inflammation and a biomarker of tissue injury, feline IL-1α is important in studies of mucosal immunity, chronic inflammatory disease, and host-pathogen interactions. In translational research, cats serve as valuable spontaneous models for human inflammatory and oral mucosal diseases, and characterization of feline IL-1α supports comparative investigations into cytokine-driven pathology and development of targeted anti-inflammatory therapies relevant to both veterinary and human medicine.
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