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Swine IL-1 beta Recombinant Protein
- Catalog Number:
- RP0297S
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Sus scrofa (pig)
- Swine IL-1β (catalog RP0297S) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~17.6 kDa, 153 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-1β signaling, inflammation, inflammasome/pyroptosis and innate immune responses; typical experimental uses include cell-culture stimulation and dosing studies, cytokine and inflammasome assays, ELISA and neutralization assays, receptor-binding and signaling studies, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | ANVQSMECKL QDKDHKSLVL AGPHMLKALH LLTGDLKREV VFCMSFVQGD DSNNKIPVTL GIKGKNLYLS CVMKDNTPTL QLEDIDPKRY PKRDMEKRFV FYKTEIKNRV EFESALYPNW YISTSQAEQK PVFLGNSKGR QDITDFTMEV LSP (153) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 17.6 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Swine Interleukin-1 Beta (IL-1β) is a potent pro-inflammatory cytokine produced primarily by activated macrophages, monocytes, and dendritic cells in pigs (Sus scrofa domesticus) in response to infection, tissue injury, or inflammatory stimuli. Synthesized as an inactive precursor (pro-IL-1β), it is cleaved into its active form by caspase-1 within inflammasome complexes-most notably the NLRP3 inflammasome-and subsequently signals through the IL-1 receptor type 1 (IL-1R1), activating NF-κB and MAPK pathways that promote fever, leukocyte recruitment, endothelial activation, and acute-phase protein production. In swine health, IL-1β plays a central role in inflammatory responses associated with economically significant diseases such as porcine reproductive and respiratory syndrome (PRRS), swine influenza, African swine fever, enteric infections, bacterial pneumonia, and sepsis, where excessive IL-1β production can contribute to lung injury, systemic inflammation, and reduced growth performance. As a biomarker of innate immune activation, IL-1β is widely used in vaccine evaluation, disease pathogenesis studies, and immune monitoring in swine production systems. In translational research, pigs serve as valuable large-animal models due to their physiological and immunological similarities to humans, and characterization of swine IL-1β supports studies of inflammasome biology, cytokine-driven pathology, sepsis, trauma, and development of targeted anti-inflammatory therapies relevant to both veterinary and human medicine.
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