Chicken IL-6 Recombinant Protein

Catalog Number:: RP0299C
Availability:: In stock
Application:: Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
100% Homology:: Gallus gallus (chicken)

Chicken IL-6 (catalog RP0299C) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~22.0 kDa, 195 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to chicken. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-6 signaling, acute-phase and inflammatory responses, and B-cell differentiation; typical experimental uses include cell-culture stimulation and dosing studies, proliferation/differentiation assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.

Amino Acid Sequence	VPLPAAADSS GEVGLEEEAG ARRALLDCEP LARVLRDRAV QLQDEMCKKF TVCENSMEML VRNNLNLPKV TEEDGCLLAG FDEEKCLTKL SSGLFAFQTY LEFIQETFDS EKQNVESLCY STKHLAATIR QMVINPDEVV IPDSAAQKSL LANLKSDKDW IEKITMHLIL RDFTSFMEKT VRAVRYLKKT RSFSA (195)
Endotoxin	Naturally endotoxin-free

Storage Conditions	-20°C
Molecular Weight	22.0 kDa
Purity	>98% as visualized by SDS-PAGE analysis.
Country Of Origin	USA

Chicken Interleukin-6 (chIL-6) is a multifunctional pro-inflammatory cytokine that plays a central role in regulating innate and adaptive immune responses in avian species. Although the avian IL-6 cytokine system differs structurally from its mammalian counterparts, chicken IL-6 functionally parallels members of the mammalian IL-6 family by signaling through receptor complexes involving gp130 to activate JAK/STAT pathways and drive acute-phase responses, B-cell differentiation, and inflammatory gene expression. In chickens (Gallus gallus), IL-6 is rapidly induced in response to bacterial, viral, and parasitic infections-including avian influenza virus, Newcastle disease virus, infectious bursal disease virus, Salmonella, and Eimeria species-and contributes to fever, hepatic acute-phase protein production, and leukocyte activation. Dysregulated IL-6 expression is associated with excessive inflammation, reduced growth performance, and increased morbidity, making it an important biomarker for disease severity, vaccine response, and flock health monitoring in poultry production. In animal health and research settings, characterization of chicken IL-6 supports studies of host-pathogen interactions, mucosal immunity, vaccine development, and immune modulation strategies aimed at improving disease resistance, productivity, and welfare in commercial poultry systems.

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