Swine IL-4 (Yeast-derived Recombinant Protein) - 5 micrograms

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Swine IL-4 Specifications

Molecular Weight (calculated) - 12.5kDa


Gene ID - 397225

Homology Across Species
Sus scrofa (pig) IL-4 – 100%
Phacochoerus africanus (Common warthog) IL-4 – 100%
More -

Endotoxin - Naturally endotoxin-free


Cell Culture, ELISA Standard, Western Blot Control

IL-4 Background

Interleukin-4 (IL-4) induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4. IL-4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. IL-4 induces B-cell class switching to IgE, and up-regulates MHC class II production. Overproduction of IL-4 is associated with allergies.

Alternate Names - IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4, interleukin 4

Swine IL-4 (Yeast-derived Recombinant Protein) - 5 micrograms
Catalog No.:
5 ug
The Swine IL-4 recombinant protein was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
The Swine IL-4 recombinant protein has a predicted molecular weight of 12.5 kDa.
Protein Sequence:
Country of Origin:
The Swine IL-4 endotoxin-free recombinant protein can be used in cell culture, as an IL-4 ELISA Standard, and as a Western Blot Control.


A Nanoparticle-Poly(I:C) Combination Adjuvant Enhances the Breadth of the Immune Response to Inactivated Influenza Virus Vaccine in Pigs.

Renu S, Feliciano-Ruiz N, Lu F, Ghimire S, Han Y, Schrock J, Dhakal S, Patil V, Krakowka S, HogenEsch H, Renukaradhya GJ.

Vaccines (Basel). 2020 May 18;8(2):E229. doi: 10.3390/vaccines8020229.

Applications: IL-4 and GM-CSF were used to generate dendritic cells from porcine monocytes in culture.


Intranasal vaccination elicits secretory IgA (SIgA) antibodies in the airways, which is required for cross-protection against influenza. To enhance the breadth of immunity induced by a killed swine influenza virus antigen (KAg) or conserved T cell and B cell peptides, we adsorbed the antigens together with the TLR3 agonist poly(I:C) electrostatically onto cationic alpha-D-glucan nanoparticles (Nano-11) resulting in Nano-11-KAg-poly(I:C) and Nano-11-peptides-poly(I:C) vaccines. In vitro, increased TNF-α and IL-1ß cytokine mRNA expression was observed in Nano-11-KAg-poly(I:C)-treated porcine monocyte-derived dendritic cells. Nano-11-KAg-poly(I:C), but not Nano-11-peptides-poly(I:C), delivered intranasally in pigs induced high levels of cross-reactive virus-specific SIgA antibodies secretion in the nasal passage and lungs compared to a multivalent commercial influenza virus vaccine administered intramuscularly. The commercial and Nano-11-KAg-poly(I:C) vaccinations increased the frequency of IFNγ secreting T cells. The poly(I:C) adjuvanted Nano-11-based vaccines increased various cytokine mRNA expressions in lymph nodes compared to the commercial vaccine. In addition, Nano-11-KAg-poly(I:C) vaccine elicited high levels of virus neutralizing antibodies in bronchoalveolar lavage fluid. Microscopic lung lesions and challenge virus load were partially reduced in poly(I:C) adjuvanted Nano-11 and commercial influenza vaccinates. In conclusion, compared to our earlier study with Nano-11-KAg vaccine, addition of poly(I:C) to the formulation improved cross-protective antibody and cytokine response.

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