Swine CXCL9 (MIG) Recombinant Protein

Catalog Number:: RP0309S
Availability:: In stock
Application:: Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
100% Homology:: Sus scrofa (pig)

Swine CXCL9 (catalog RP0309S) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~12.1 kDa, 104 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study chemokine signaling and leukocyte chemoattraction/migration (particularly CXCR3⁺ T cells and NK cells), inflammation and immune-cell trafficking; typical experimental uses include chemotaxis and cell-migration assays, receptor-binding and signaling studies, cell-culture stimulation and dosing, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.

Amino Acid Sequence	TLLMRNGRCS CINTSQRMIH LKSLRDLKQF APSPSCEKME VIATMKNGDQ TCLNPDSPDV KKLIKEWEKQ VSLKKKQKKG KKHPKTKKVR KVKKSQRPDQ KKMT (104)
Endotoxin	Naturally endotoxin-free

Storage Conditions	-20°C
Molecular Weight	12.1 kDa
Purity	>98% as visualized by SDS-PAGE analysis.
Country Of Origin	USA

Swine CXCL9 (C-X-C motif chemokine ligand 9), also known as MIG (monokine induced by interferon-γ), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL10 (IP-10) and CXCL11 (I-TAC) that regulate T-cell recruitment during interferon-driven immune responses. In pigs (Sus scrofa), CXCL9 is produced by macrophages, dendritic cells, endothelial cells, and epithelial cells in response to interferon-γ (IFN-γ) and inflammatory stimuli during infection or immune activation. CXCL9 signals primarily through the chemokine receptor CXCR3, expressed on activated T lymphocytes, natural killer (NK) cells, and other immune cells, promoting chemotaxis and accumulation of these cells at sites of infection or inflammation. In swine health, CXCL9 contributes to Th1-type immune responses against intracellular pathogens, particularly in tissues such as the lung and lymphoid organs during viral and bacterial infections. Pigs are also used as translational animal models for human respiratory and infectious diseases, including influenza virus infection, where CXCL9 is part of the interferon-driven chemokine network that recruits CXCR3⁺ T cells to infected lung tissue, helping regulate antiviral immunity and inflammatory responses relevant to both veterinary and human biomedical research.

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