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Guinea Pig IL-1 beta Recombinant Protein
- Catalog Number:
- RP0343GP
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Cavia porcellus (domestic guinea pig)
- Guinea Pig IL-1β (catalog RP0343GP) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~17.2 kDa, 152 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to guinea pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-1β signaling, inflammation, inflammasome/pyroptosis and innate immune responses; typical experimental uses include cell-culture stimulation and dosing studies, cytokine and inflammasome assays, ELISA and neutralization assays, receptor-binding and signaling studies, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | TPVPSRNCTL HDIQHKRLVL SDPCELKALH LNGDNLNRQV VFSMSFVQGE RSDNKMPVAL GLKGKNLYLS CVMKDGKPVL QLESVDGKQY PKKKMEKRFV FNKITSKSTV EFESAQFPNW YISTSQAEHK PVFLGNNNGQ DIIDFKLELV SS (152) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 17.2 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Guinea Pig Interleukin-1 Beta (IL-1β) is a potent pro-inflammatory cytokine produced primarily by activated macrophages, monocytes, and dendritic cells in guinea pigs (Cavia porcellus) following recognition of pathogens or tissue injury. Synthesized as an inactive precursor (pro-IL-1β), it is cleaved into its active form by caspase-1 within the inflammasome complex and signals through the IL-1 receptor (IL-1R1), activating NF-κB and MAPK pathways that promote fever, leukocyte recruitment, vascular permeability, and amplification of inflammatory responses. In guinea pig health and research, IL-1β is prominently induced in pulmonary tissues during infections such as Mycobacterium tuberculosis, influenza virus, and other respiratory pathogens, contributing to granuloma formation, neutrophil infiltration, and tissue pathology. Because guinea pigs are widely used as translational models for tuberculosis, influenza, cytomegalovirus, and certain viral hemorrhagic fevers, characterization of IL-1β is critical for understanding inflammasome activation, cytokine-mediated lung injury, and host-pathogen interactions. As both a biomarker and functional mediator of innate immune activation, guinea pig IL-1β supports preclinical research in infectious disease, vaccine development, and evaluation of anti-inflammatory or immunomodulatory therapies relevant to human inflammatory and respiratory diseases.
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