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Guinea Pig IL-8 Recombinant Protein
- Catalog Number:
- RP0344GP
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Cavia porcellus (domestic guinea pig)
- Guinea Pig IL-8 (catalog RP0344GP) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~9.1 kDa, 79 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to guinea pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study chemokine signaling and leukocyte (particularly neutrophil) chemoattraction/migration; typical experimental uses include chemotaxis and cell-migration assays, cell-culture stimulation and dosing studies, receptor-binding and signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | MVVTKLVSEL RCQCIKIHTT PFHPKFIKEL KVIESGPRCA NSEIIVKLSD NRQLCLDPKK KWVQDVVSMF LKRTESQDS (79) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 9.1 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Guinea Pig Interleukin-8 (IL-8), also known as CXCL8, is a pro-inflammatory chemokine that plays a central role in innate immune responses in guinea pigs (Cavia porcellus) by mediating neutrophil chemotaxis, activation, and recruitment to sites of infection or tissue injury. Produced by macrophages, epithelial cells, and endothelial cells in response to microbial products and inflammatory cytokines, guinea pig IL-8 signals through CXCR1 and CXCR2 receptors to drive neutrophil migration and amplification of local inflammatory responses. IL-8 is significantly upregulated in pulmonary tissues during infections such as Mycobacterium tuberculosis, influenza virus, and other respiratory pathogens, contributing to granulocytic infiltration and lung pathology. Because guinea pigs are well-established models for tuberculosis, influenza, cytomegalovirus, and certain hemorrhagic fever viruses, characterization of IL-8 is critical for understanding neutrophil-driven inflammation, granuloma formation, and cytokine-mediated tissue damage. As both a biomarker and functional mediator of acute inflammation, guinea pig IL-8 supports translational research in respiratory disease, vaccine development, and host-pathogen interaction studies relevant to human infectious and inflammatory disorders.
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