Guinea Pig Interleukin-8 (IL-8), also known as CXCL8, is a pro-inflammatory chemokine that plays a central role in innate immune responses in guinea pigs (Cavia porcellus) by mediating neutrophil chemotaxis, activation, and recruitment to sites of infection or tissue injury. Produced by macrophages, epithelial cells, and endothelial cells in response to microbial products and inflammatory cytokines, guinea pig IL-8 signals through CXCR1 and CXCR2 receptors to drive neutrophil migration and amplification of local inflammatory responses. IL-8 is significantly upregulated in pulmonary tissues during infections such as Mycobacterium tuberculosis, influenza virus, and other respiratory pathogens, contributing to granulocytic infiltration and lung pathology. Because guinea pigs are well-established models for tuberculosis, influenza, cytomegalovirus, and certain hemorrhagic fever viruses, characterization of IL-8 is critical for understanding neutrophil-driven inflammation, granuloma formation, and cytokine-mediated tissue damage. As both a biomarker and functional mediator of acute inflammation, guinea pig IL-8 supports translational research in respiratory disease, vaccine development, and host-pathogen interaction studies relevant to human infectious and inflammatory disorders.