Guinea Pig CCL5 (C–C motif chemokine ligand 5, also known as RANTES – Regulated upon Activation, Normal T cell Expressed and Secreted) is a proinflammatory chemokine that regulates immune cell recruitment and inflammatory responses in guinea pigs (Cavia porcellus). CCL5 belongs to the CC chemokine family, which also includes CCL3 (MIP-1α), CCL4 (MIP-1β), and CCL2 (MCP-1), chemokines that coordinate leukocyte trafficking during immune activation. In guinea pigs, CCL5 is produced primarily by activated T lymphocytes, macrophages, dendritic cells, platelets, and epithelial cells in response to infection, inflammatory stimuli, or tissue injury, and it exerts its biological effects mainly through binding to the chemokine receptors CCR1, CCR3, and CCR5, promoting chemotaxis and activation of T cells, monocytes/macrophages, eosinophils, and natural killer (NK) cells at sites of inflammation. Guinea pigs are widely used as animal models for infectious and inflammatory diseases, particularly tuberculosis caused by Mycobacterium tuberculosis and respiratory infections, where chemokines such as CCL5 contribute to recruitment of immune cells, granuloma formation, and regulation of inflammatory responses. Consequently, guinea pig CCL5 is studied in immunology, infectious disease research, and vaccine development, helping to clarify mechanisms of chemokine-mediated leukocyte recruitment and host defense in disease models relevant to human health.