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Guinea Pig CCL11 (Eotaxin-1) Recombinant Protein
- Catalog Number:
- RP0349GP
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Cavia porcellus (domestic guinea pig)
- Guinea Pig CCL11 (catalog RP0349GP) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~8.4 kDa, 73 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to guinea pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study chemokine signaling and leukocyte chemoattraction/migration (particularly eosinophil recruitment); typical experimental uses include chemotaxis and cell-migration assays, cell-culture stimulation and dosing studies, receptor-binding studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | HPGIPSACCF RVTNKKISFQ RLKSYKIITS SKCPQTAIVF EIKPDKMICA DPKKKWVQDA KKYLDQISQT TKP (73) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 8.4 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Guinea pig CCL11 (C-C motif chemokine ligand 11), also known as eotaxin-1, is a member of the CC chemokine family that plays a central role in regulating eosinophil recruitment and type 2-associated immune responses in guinea pigs (Cavia porcellus). CCL11 is produced primarily by epithelial cells, fibroblasts, endothelial cells, and activated immune cells in response to Th2-associated cytokines such as IL-4 and IL-13, and it functions predominantly through the CCR3 receptor to promote chemotaxis and activation of eosinophils, as well as certain Th2 lymphocytes and basophils. In healthy guinea pigs, basal CCL11 expression is typically low, but levels increase during allergic inflammation, parasitic infection, airway hyperresponsiveness, and experimental immune stimulation. In biomedical research, guinea pig CCL11 is particularly relevant in models of asthma, allergic airway inflammation, anaphylaxis, and helminth infection, where eosinophilic infiltration and Th2 polarization are key features of disease pathology. Characterization of CCL11 in guinea pigs provides valuable insight into eosinophil biology, chemokine-driven leukocyte trafficking, and mechanisms underlying allergic and type 2-mediated inflammatory responses in translational respiratory and immunology research.
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