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Bovine Receptor Antagonist (IL-1RA) Recombinant Protein
- Catalog Number:
- RP0351B
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Bison bison bison (American buffalo), Bos indicus (zebu), Bos mutus (wild yak), Bos taurus (cattle), Bubalus bubalis (water buffalo)
- Bovine IL-1RA (catalog RP0351B) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~17.2 kDa, 151 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology across several bovine species (cattle, American buffalo, zebu, wild yak and water buffalo). Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-36/IL-1 family signaling, IL-1 receptor antagonism and the regulation of inflammatory responses; typical experimental uses include cell-culture stimulation and dosing studies, cytokine signaling and inhibition assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | HPLGKRRCEM QAFRIWDVNQ KIFYLRNNQL VAGYLQGPNT KLEEKIDVVP IEPHTMFLGI HGGKLCLACV KSGDEIKLKL EAVNITDLNQ NREQDKRFAF IRFDNGPTTS FESAACPGWF LCTSLEADQP VGLTNMPTEA LKVTKFYFQQ D (151) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 17.2 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Bovine Interleukin-1 Receptor Antagonist (IL-1Ra) is an anti-inflammatory cytokine produced by monocytes, macrophages, neutrophils, and other immune cells in cattle (Bos taurus) that functions as a natural regulator of IL-1-mediated inflammation. IL-1Ra competitively binds to the IL-1 receptor type 1 (IL-1R1) without triggering downstream signaling, thereby inhibiting the pro-inflammatory effects of IL-1α and IL-1β and limiting activation of NF-κB and MAPK pathways. In bovine health, IL-1Ra plays an important role in modulating inflammatory responses associated with economically significant conditions such as mastitis, bovine respiratory disease (BRD), metritis, lameness, and enteric infections, helping to balance pathogen clearance with prevention of excessive tissue damage. Elevated IL-1Ra expression in the mammary gland during intramammary infection reflects its role in controlling neutrophil-driven inflammation and supporting resolution of inflammation. As a biomarker of anti-inflammatory regulation, bovine IL-1Ra is valuable in studies of immune balance, vaccine responses, and disease progression. In veterinary and translational research, characterization of bovine IL-1Ra supports investigations into inflammasome regulation, cytokine network dynamics, and development of strategies to mitigate excessive inflammation while preserving protective immunity in large-animal systems relevant to both livestock health and comparative immunology.
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