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Interleukin-8 (IL-8), also known as CXCL8, is a CXC family member chemokine produced by macrophages and other cell types such as epithelial cells. There have been 17 different CXC chemokines described in mammals, that are subdivided into two categories, those with a specific amino acid sequence (or motif) of glutamic acid-leucine-arginine (or ELR for short) immediately before the first cysteine of the CXC motif (ELR-positive), and those without an ELR motif (ELR-negative). ELR-positive CXC chemokines such as IL-8 specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2.
Alternate Names - CXCL8, chemokine (C-X-C motif) ligand 8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1, IL8, C-X-C motif chemokine ligand 8, Interleukin-8, SCYB8
IL-8 Homology Across Species
Homo sapiens (human) IL-8 – 100%
Gorilla gorilla gorilla (western lowland gorilla) IL-8 – 100%
Pan paniscus (pygmy chimpanzee) IL-8 – 100%
Pan troglodytes (chimpanzee) IL-8 – 100%
Pongo abelii (Sumatran orangutan) IL-8 – 100%
Nomascus leucogenys (northern white-cheeked gibbon) IL-8 – 97%
Colobus angolensis palliates (Peter’s Angolan Colobus) IL-8 – 96%
Macaca fascicularis (Cynomolgus monkey) IL-8 – 96%
Macaca mulatta (Rhesus monkey) IL-8 -96%
Macaca nemestrina (pig-tailed macaque) IL-8 – 96%
Papio anubis (olive baboon) IL-8 – 96%
Rhinopithecus bieti (black snub-nosed monkey) IL-8 – 96%
Rhinopithecus roxellana (golden snub-nosed monkey) IL-8 – 96%
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