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Equine IL-1 alpha Recombinant Protein
- Catalog Number:
- RP0358E
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Equus caballus (horse)
- Equine IL-1α (catalog RP0358E) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~18.1 kDa, 158 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to horse. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-1α signaling, inflammation and innate immune responses; typical experimental uses include cell-culture stimulation and dosing studies, cytokine and inflammasome assays, ELISA and neutralization assays, receptor-binding and signaling studies, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | SVHYNFQSNT KYNFMRIVNH QCTLNDALNQ SVIRDTSGQY LATAALNNLD DAVKFDMGAY TSEEDSQLPV TLRISKTRLF VSAQNEDEPV LLKEMPDTPK TIKDETNLLF FWERHGSKNY FKSVAHPKLF IATKQGKLVH MARGQPSITD FQILDNQF (158) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 18.1 kda |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Equine Interleukin-1 Alpha (IL-1α) is a pro-inflammatory cytokine belonging to the IL-1 family-which includes IL-1α, IL-1β, and the IL-1 receptor antagonist (IL-1Ra)-and plays a pivotal role in initiating innate immune responses in horses (Equus caballus). IL-1α is constitutively expressed in epithelial and barrier tissues and acts as an intracellular alarmin that is rapidly released upon cell injury, necrosis, or mechanical stress, triggering early inflammatory signaling. Upon binding to the IL-1 receptor type 1 (IL-1R1), IL-1α activates NF-κB and MAPK pathways that promote leukocyte recruitment, endothelial activation, fever, and amplification of pro-inflammatory cytokine cascades. In equine health, IL-1α is particularly important in musculoskeletal inflammation such as osteoarthritis and synovitis, where it contributes to cartilage matrix degradation and synovial inflammation, as well as in laminitis, colitis, endotoxemia, and respiratory inflammatory conditions. While critical for initiating protective immune responses and tissue repair, excessive or sustained IL-1α signaling can exacerbate tissue damage and systemic inflammatory responses. As an early mediator of sterile and infectious inflammation, equine IL-1α serves as a biomarker of tissue injury and innate immune activation. In veterinary and translational research, characterization of equine IL-1α supports studies of joint disease pathogenesis, systemic inflammatory response syndrome (SIRS), cytokine regulation, and development of targeted anti-inflammatory and regenerative therapies relevant to both equine and human inflammatory diseases.
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