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Guinea Pig CCL2 (MCP-1) Recombinant Protein
- Catalog Number:
- RP0362GP
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Cavia porcellus (domestic guinea pig)
- Guinea Pig CCL2 (MCP-1) (catalog RP0362GP) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~11.2 kDa, 97 amino acids long (full sequence provided, note: material contains a Gln79 to Pro substitution), and >98% pure by SDS-PAGE, with 100% amino-acid homology to guinea pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study chemokine signaling and monocyte/macrophage chemoattraction and migration; typical experimental uses include chemotaxis and cell-migration assays, cell-culture stimulation and dosing studies, receptor-binding and signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | QPDGVNTPTC CYTFNKQIPL KRVKGYERIT SSRCPQEAVI FRTLKNKEVC ADPTQKWVQD YIAKLDQRTQ QKQNSTAPPT SKPLNIRFTT QDPKNRS (97) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 11.2 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Guinea Pig CCL2 (C-C motif chemokine ligand 2, also known as monocyte chemoattractant protein-1, MCP-1) is a pro-inflammatory chemokine that regulates recruitment and activation of monocytes, macrophages, and memory T cells during immune responses in guinea pigs (Cavia porcellus). CCL2 signals primarily through the CCR2 receptor, activating intracellular pathways that promote leukocyte migration, cytokine production, and coordination of innate and adaptive immune responses at sites of infection or tissue injury. In guinea pig health and research, CCL2 is particularly important in respiratory and infectious disease models, including tuberculosis (Mycobacterium tuberculosis), where macrophage recruitment and granuloma formation are key components of disease pathogenesis. CCL2-mediated signaling contributes to the accumulation of monocytes and macrophages within infected lung tissue, influencing granuloma structure, immune containment of pathogens, and inflammatory damage. While CCL2-driven immune cell trafficking supports host defense, excessive or sustained expression can contribute to chronic inflammation and tissue pathology. Because guinea pigs are widely used as translational models for tuberculosis, respiratory infections, and inflammatory lung disease, characterization of guinea pig CCL2 supports studies of chemokine-mediated immune cell recruitment, host-pathogen interactions, and inflammatory mechanisms relevant to human infectious and inflammatory diseases.
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