Mouse Basic Fibroblast Growth Factor (FGF2, also known as bFGF) is a heparin-binding growth factor belonging to the fibroblast growth factor (FGF) family, which includes more than 20 related proteins that regulate cell proliferation, differentiation, angiogenesis, and tissue repair. In mice (Mus musculus), FGF2 is produced by fibroblasts, endothelial cells, macrophages, neurons, and other stromal and epithelial cells, where it plays key roles in development, wound healing, and vascular growth. FGF2 binds to fibroblast growth factor receptors (FGFR1–FGFR4) in the presence of heparan sulfate proteoglycans, activating intracellular signaling pathways such as MAPK/ERK, PI3K–AKT, and PLCγ, which promote cell proliferation, survival, migration, and angiogenesis. In murine physiology, FGF2 is particularly important in neurodevelopment, skeletal development, and tissue regeneration, including skin and vascular repair. Mice are widely used as animal models for studying growth factor signaling and regenerative biology, and FGF2 has been extensively investigated in mouse models of wound healing and angiogenesis, where FGF2 signaling regulates endothelial cell proliferation and new blood vessel formation, helping researchers understand mechanisms of tissue repair, cancer growth, and therapeutic angiogenesis relevant to human medicine.