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Ovine VEGF-A Recombinant Protein
- Catalog Number:
- RP0426V
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Oryx dammah (scimitar-horned oryx), Ovis aries (sheep), Pantholops hodgsonii (chiru)
- Ovine VEGF-A (catalog RP0426V) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~14.1 kDa, 120 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to sheep, scimitar-horned oryx, and chiru. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study VEGF signaling and angiogenesis (including endothelial-cell proliferation, migration, and vascular permeability); typical experimental uses include cell-culture stimulation and dosing studies, proliferation and migration assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | APMAEGGQKP HEVMKFMDVY QRSFCRPIET LVDIFQEYPD EIEFIFKPSC VPLMRCGGCC NDESLECVPT EEFNITMQIM RIKPHQSQHI GEMSFLQHNK CECRPKKDKA RQEKCDKPRR (120) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 14.1 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Ovine Vascular Endothelial Growth Factor A (VEGF-A) is a member of the vascular endothelial growth factor (VEGF) family, which includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, and placental growth factor (PlGF)-key regulators of angiogenesis, vascular permeability, and endothelial cell growth. In sheep (Ovis aries), VEGF-A is produced by a variety of cell types including endothelial cells, macrophages, fibroblasts, epithelial cells, smooth muscle cells, and trophoblast cells, particularly in response to hypoxia, inflammation, and tissue injury. VEGF-A exerts its biological effects primarily through binding to VEGF receptor-1 (VEGFR-1/Flt-1) and VEGF receptor-2 (VEGFR-2/KDR) on endothelial cells, activating intracellular signaling pathways such as MAPK/ERK, PI3K/AKT, and PLCγ, which promote endothelial cell proliferation, migration, vascular permeability, and formation of new blood vessels. In ovine physiology, VEGF-A plays important roles in placental vascular development, reproductive function, fetal growth, and tissue repair, supporting the formation of an adequate maternal-fetal blood supply during pregnancy. VEGF-A is also involved in wound healing and vascular remodeling following tissue injury. Because sheep are widely used as large-animal models for cardiovascular physiology, placental biology, and fetal development, ovine VEGF-A is studied in research on angiogenesis, reproductive biology, and vascular regulation, providing insights relevant to both livestock health and translational biomedical research.
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