Slide 1 of 1 
Canine IL-1 Receptor Antagonist (IL-1RA) Recombinant Protein
- Catalog Number:
- RP0427D
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Canis lupus dingo (dingo), Canis lupus familiaris (dog), Nyctereutes procyonoides (raccoon dog), Vulpes lagopus (Arctic fox), Vulpes vulpes (red fox)
- Canine IL-1 receptor antagonist (catalog RP0427D) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~16.8 kDa, 149 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to dog, dingo, raccoon dog, Arctic fox, and red fox. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-1 signaling and inflammatory regulation (including inhibition of IL-1-mediated responses); typical experimental uses include cell-culture stimulation and inhibition studies, cytokine signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | LGKRPCRMQA FRIWDVNQKT FYLRNNQLVA GYLQGSNTKL EEKLDVVPVE PHAVFLGIHG GKLCLACVKS GDETRLQLEA VNITDLSKNK DQDKRFTFIL SDSGPTTSFE SAACPGWFLC TALEADRPVS LTNRPEEAMM VTKFYFQKE (149) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 16.8 kda |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Canine Interleukin-1 Receptor Antagonist (IL-1Ra) is an anti-inflammatory cytokine produced by monocytes, macrophages, neutrophils, and other immune cells in dogs (Canis lupus familiaris) that serves as a natural regulator of IL-1-mediated inflammation. IL-1Ra competitively binds to the IL-1 receptor type 1 (IL-1R1) without activating downstream signaling, thereby blocking the pro-inflammatory effects of IL-1α and IL-1β and limiting activation of NF-κB and MAPK pathways that drive fever, leukocyte recruitment, and tissue inflammation. In canine health, IL-1Ra plays an important role in modulating inflammatory conditions such as osteoarthritis, immune-mediated polyarthritis, atopic dermatitis, inflammatory bowel disease, sepsis, and other inflammatory or infectious diseases where excessive IL-1 signaling contributes to pathology. In joint disease specifically, IL-1Ra helps counteract IL-1β-driven cartilage degradation and synovial inflammation, making it relevant to therapeutic strategies including biologic and regenerative medicine approaches. As both a biomarker of anti-inflammatory regulation and a therapeutic target, canine IL-1Ra is important in veterinary medicine for monitoring inflammatory balance and evaluating treatment efficacy. In translational research, dogs serve as valuable spontaneous models for human osteoarthritis, autoimmune disorders, and inflammatory diseases, and characterization of canine IL-1Ra supports studies of cytokine network regulation, resolution of inflammation, and development of targeted immunomodulatory therapies relevant to both canine and human health.
Please choose a size to see price
RELATED MEDIA
