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Human IL-19 Recombinant Protein
- Catalog Number:
- RP0438H
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Homo sapiens (human)
- Human IL-19 (catalog RP0438H) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~17.8 kDa, 153 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to human. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-19 signaling and immune regulation (including modulation of inflammatory and Th2-type responses); typical experimental uses include cell-culture stimulation and dosing studies, signaling and gene-expression assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | LRRCLISTDM HHIEESFQEI KRAIQAKDTF PNVTILSTLE TLQIIKPLDV CCVTKNLLAF YVDRVFKDHQ EPNPKILRKI SSIANSFLYM QKTLRQCQEQ RQCHCRQEAT NATRVIHDNY DQLEVHAAAI KSLGELDVFL AWINKNHEVM FSA (153) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 17.8 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Human IL-19 (Interleukin-19) is a member of the IL-10 cytokine family that functions primarily as an immunomodulatory cytokine involved in regulation of inflammatory responses. IL-19 is produced predominantly by monocytes, macrophages, epithelial cells, keratinocytes, and other tissue-resident cells in response to pro-inflammatory stimuli such as IL-1β and TNF-α. It signals through the heterodimeric IL-20 receptor complex (IL-20R1/IL-20R2), activating downstream pathways including STAT3, which contribute to modulation of cytokine production and immune cell activity. IL-19 is generally associated with Th2-skewed immune responses and can promote production of IL-4, IL-5, and IL-13 while dampening excessive Th1-mediated inflammation. In healthy individuals, circulating IL-19 levels are typically low but increase during inflammatory and autoimmune conditions. Elevated IL-19 expression has been implicated in psoriasis, atopic dermatitis, asthma, inflammatory bowel disease, rheumatoid arthritis, and certain cardiovascular and fibrotic disorders. In clinical and translational research, human IL-19 serves as a biomarker of immune dysregulation and epithelial inflammation and is being investigated as both a mediator and potential therapeutic target in chronic inflammatory and immune-mediated diseases.
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