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Rabbit IL-17A (Yeast-derived Recombinant Protein) - 500 ug (5 x 100 ug vials)

RP0456U-500
$3300.00
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Bulk quantities of proteins are available. Please contact us for bulk pricing.

IL-17A is a member of the IL-17 family, which is comprised of 6 members [IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F]. IL-17 family members are involved in numerous immune regulatory functions, including inducing and mediating proinflammatory responses and allergic responses. Il-17 induces the production of many other cytokines (IL-6, G-CSF, GM-CSF, IL-1beta, TGF-beta, and TNF-alpha), chemokines, including IL-8 (CXCL8), GRO-alpha (CXCL1) and MCP-1 (CCL2) and prostaglandins from many cell types (fibroblasts, endothelial cells, epithelial cells, keratinocytes and macrophages).

Alternate Names - IL17A, CTLA8, IL-17, IL-17A, IL17, CTLA-8, interleukin 17A

IL-17A Homology Across Species
Oryctolagus cuniculus (rabbit) IL-17A – 100%
More… https://blast.ncbi.nlm.nih.gov

Rabbit IL-17A (Yeast-derived Recombinant Protein) - 500 ug (5 x 100 ug vials)
Catalog No.:
RP0456U-500
Quantity:
500 ug (5 x 100 ug vials)
Source:
The Rabbit IL-17A recombinant protein was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.
MW:
The Rabbit IL-17A recombinant protein has a predicted molecular weight of 14.9 kDa.
Protein Sequence:
GIAMPRNPGC PNAEDKNFPQ NVKVSLNILN KSVNSRRPSD YYNRSTSPWT LHRNEDHERY PSVIWEAKCR HLGCVNAEGN VDHHMNSVPI QQEILVLRRE SQHCPHSFRL EKMLVAVGCT CVTPIIHHMA (130)
Country of Origin:
USA
Applications:
The rabbit IL-17A endotoxin-free recombinant protein can be used in cell culture, as a IL-17A ELISA Standard, and as a Western Blot Control.

28222511

Evaluation of a DNA Aβ42 Vaccine in Aged NZW Rabbits: Antibody Kinetics and Immune Profile after Intradermal Immunization with Full-Length DNA Aβ42 Trimer.

Lambracht-Washington D, Fu M, Wight-Carter M, Riegel M, Rosenberg RN.

J Alzheimers Dis. 2017;57(1):97-112. doi: 10.3233/JAD-160947.

Applications: Determine frequencies of cytokine secreting cells by ELISPOT for rabbit IFN gamma, IL-17A, and IL-4.

Abstract
A pathological hallmark of Alzheimer's disease (AD) are amyloid plaques in the brain consisting of aggregated amyloid-β 42 peptide (Aβ42) derived from cellular amyloid-β protein precursor (AβPP). Based on successful experiments in mouse AD models, active immunization with Aβ42 peptide and passive immunizations with anti-Aβ42 antibodies were started in clinical trials. Active Aβ42 peptide immunization in humans had led to an inflammatory autoimmune response, and the trial was stopped. Passive immunizations had shown some effects in slowing AD pathology. Active DNA Aβ42 immunizations administered with the gene gun into the skin elicits a different immune response and is non-inflammatory. While in rodents, good responses had been found for this type of immunization, positive results in larger mammals are missing. We present here results from sixteen New Zealand White Rabbits, which underwent intradermal DNA Aβ42 immunization via gene gun. The humoral immune response was analyzed from blood throughout the study, and cellular immune responses were determined from spleens at the end of the study. A good anti-Aβ antibody response was found in the rabbit model. The T cell response after re-stimulation in cell culture showed no IFNγ producing cells when ELISPOT assays were analyzed from PBMC, but low numbers of IFNγ and IL-17 producing cells were found in ELISPOTS from spleens (both 5 immunizations). Brains from immunized rabbits showed no signs of encephalitis. Based on these results, DNA Aβ42 immunization is highly likely to be safe and effective to test in a possible clinical AD prevention trial in patients.


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