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Multi-species (Bovine, Ovine, Caprine) BAFF Recombinant Protein
- Catalog Number:
- RP0464B
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Bos mutus (wild yak), Bos taurus (cattle), Bubalus bubalis (water buffalo), Capra hircus (goat), Oryx dammah (scimitar-horned oryx), Ovis aries (sheep)
- Bovine, Ovine, and Caprine BAFF (catalog RP0464B) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~17.1 kDa, 152 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to cattle, sheep, goat, water buffalo, yak, and scimitar-horned oryx. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study BAFF/TNFSF13B signaling and B-cell biology (including survival, maturation, and antibody production); typical experimental uses include cell-culture stimulation and dosing studies, proliferation and survival assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | ALQEAEETVT QDCLQLIADS DTPTIRKGAY TFVPWLLSFK RGRALEEKEN KILVKETGYF FIYGQVLYTD NTFAMGHLIQ RKKVHVFGDE LSLVTLFRCI QNMPETLPNN SCYSAGIAKL EEGDELQLAI PREDAKISRD GDGTFFGALK LL (152) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 17.1 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Bovine BAFF (B cell-Activating Factor), also known as BLyS or TNFSF13B, is a member of the tumor necrosis factor (TNF) superfamily and plays a critical role in B cell development, survival, and humoral immunity in cattle (Bos taurus). BAFF is produced primarily by monocytes, macrophages, dendritic cells, neutrophils, and certain stromal cells, and it signals through the receptors BAFF-R (TNFRSF13C), TACI (TNFRSF13B), and BCMA (TNFRSF17) to promote peripheral B cell maturation, immunoglobulin class switching, and maintenance of long-lived plasma cells. In cattle, BAFF supports antibody-mediated immunity in systemic and mucosal tissues, including the respiratory tract, gastrointestinal tract, and mammary gland. Dysregulated BAFF expression may contribute to chronic inflammation, persistent infection, or B cell proliferation in conditions such as bovine leukemia virus (BLV)-associated lymphoproliferative disease, mastitis, and other chronic infectious diseases. In veterinary and agricultural research, bovine BAFF is of particular interest in studies of vaccine-induced antibody responses, mucosal immunity, mastitis resistance, and comparative B cell biology. Characterizing BAFF signaling in cattle provides valuable insight into regulation of humoral immunity and strategies to enhance protective immune responses in livestock health and production systems.
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