Ovine CXCL10 (IP-10) Recombinant Protein

Catalog Number:: RP0490V
Availability:: In stock
Application:: Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
100% Homology:: Budorcas taxicolor (takin), Ovis aries (sheep)

Ovine CXCL10 (IP-10) (catalog RP0490V) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~9.4 kDa, 83 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to sheep and takin. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CXCL10/IP-10 signaling and immune-cell chemotaxis (including recruitment of activated T cells and NK cells); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.

Amino Acid Sequence	IPLSRNTRCT CIEISNGSVN PRSLEKLELI PASQSCPRVE IIATMKRNGE KRCLNPESKT IKNLLKAINK QRTKRSPRTQ KEA (83)
Endotoxin	Naturally endotoxin-free

Storage Conditions	-20°C
Molecular Weight	9.4 kDa
Purity	>98% as visualized by SDS-PAGE analysis.
Country Of Origin	USA

Ovine CXCL10 (C-X-C motif chemokine ligand 10), also known as IP-10 (Interferon gamma-induced protein 10), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL9 (MIG) and CXCL11 (I-TAC) that regulate T-cell recruitment during antiviral and inflammatory immune responses. In sheep (Ovis aries), CXCL10 is produced by macrophages, dendritic cells, epithelial cells, endothelial cells, and fibroblasts in response to interferon-γ (IFN-γ), microbial infection, or inflammatory cytokines. CXCL10 signals primarily through the chemokine receptor CXCR3, which is expressed on activated T lymphocytes, natural killer (NK) cells, and other immune cells, promoting chemotaxis and activation of these cells at sites of infection or inflammation. In ovine health, CXCL10 contributes to immune responses against viral, bacterial, and parasitic pathogens, including infections affecting the respiratory tract and gastrointestinal system. Sheep are also used as large-animal models for inflammatory lung diseases, and CXCL10 expression has been examined in ovine models of respiratory syncytial virus (RSV) infection, which mimic aspects of human infant RSV disease, where CXCL10-mediated recruitment of CXCR3⁺ T cells contributes to antiviral immunity and airway inflammation. These studies make ovine CXCL10 relevant for comparative immunology, respiratory disease research, and investigation of interferon-driven immune responses.

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