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Swine BAFF Recombinant Protein
- Catalog Number:
- RP0492S
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Phacochoerus africanus (Common warthog), Sus scrofa (pig)
- Swine BAFF (catalog RP0492S) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~17.1 kDa, 152 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig and warthog. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study BAFF/TNFSF13B signaling and B-cell biology (including survival, maturation, and antibody production); typical experimental uses include cell-culture stimulation and dosing studies, proliferation and survival assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | AAQDAEETVT QDCLQLIADS DMPTIRKGAY TFVPWLLSFK RGRALEEKEN KIVVKETGYF FIYGQVLYTD NTFAMGHLIQ RKKVHVFGDE LSLVTLFRCI QNMPETLPNN SCYSAGIAKL EEGDELQLAI PREDAKISRD GDGTFFGALK LL (152) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 17.1 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Swine BAFF (B cell-Activating Factor), also known as BLyS or TNFSF13B, is a member of the tumor necrosis factor (TNF) superfamily and plays a central role in B cell development, survival, and regulation of humoral immunity in pigs (Sus scrofa). BAFF is produced primarily by monocytes, macrophages, dendritic cells, neutrophils, and certain stromal and epithelial cells, and it signals through the receptors BAFF-R (TNFRSF13C), TACI (TNFRSF13B), and BCMA (TNFRSF17) to promote transitional and mature B cell survival, immunoglobulin class switching, and maintenance of long-lived plasma cells. In swine, BAFF supports systemic and mucosal antibody responses, including IgA production in the respiratory and gastrointestinal tracts, which are critical for defense against enteric and respiratory pathogens. Dysregulated BAFF expression may contribute to chronic inflammation, persistent infection, or abnormal B cell activation in porcine disease models. In veterinary and translational research, swine BAFF is of particular interest in studies of vaccine-induced immunity and infectious diseases such as porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus (SIV), African swine fever virus (ASFV), and enteric pathogens, as well as in comparative immunology due to physiological similarities between pigs and humans. Characterizing BAFF signaling in swine provides valuable insight into regulation of humoral immunity and strategies to enhance protective antibody responses in both agricultural and biomedical research settings.
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