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Feline VEGF-A Recombinant Protein
- Catalog Number:
- RP0654F
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Acinonyx jubatus (cheetah), Felis catus (domestic cat), Leopardus geoffroyi (Geoffroy's cat), Lynx pardinus (Spanish lynx), Prionailurus bengalensis (leopard cat), Puma concolor (puma)
- Feline VEGF-A (catalog RP0654F) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~19.0 kDa, 163 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to cat, cheetah, lynx, puma, leopard cat, and Geoffroy's cat. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study VEGF signaling and angiogenesis (including endothelial-cell proliferation, migration, and vascular permeability); typical experimental uses include cell-culture stimulation and dosing studies, proliferation and migration assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | APMADGEHKP HEVVKFMDVY QRSYCRPIET LVDIFQEYPD EIEYIFKPSC VPLMRCGGCC NDEGLECVPT EEFNITMQIM RIKPHQGQHI GEMSFLQHSK CECRPKKDRA KENPCGPCSE RRKHLFVQDP QTCKCSCKNT DSRCKARQLE LNERTCRCDK PRR (163) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 19.0 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Feline Vascular Endothelial Growth Factor A (VEGF-A) is a member of the vascular endothelial growth factor (VEGF) family, which includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, and placental growth factor (PlGF)-key regulators of angiogenesis and vascular development. In cats (Felis catus), VEGF-A is produced by a variety of cells including endothelial cells, macrophages, fibroblasts, epithelial cells, and tumor cells, particularly in response to hypoxia, inflammation, or tissue injury. VEGF-A exerts its biological effects primarily through binding to VEGF receptor-1 (VEGFR-1/Flt-1) and VEGF receptor-2 (VEGFR-2/KDR) on endothelial cells, activating intracellular signaling pathways such as MAPK/ERK, PI3K/AKT, and PLCγ, which promote endothelial cell proliferation, migration, vascular permeability, and new blood vessel formation. In feline physiology, VEGF-A plays important roles in normal vascular development, wound healing, and tissue repair. Dysregulated VEGF-A expression is associated with tumor angiogenesis in feline cancers, including mammary carcinoma, squamous cell carcinoma, and lymphoma, where increased VEGF signaling supports tumor growth and metastasis by promoting blood vessel formation. Because angiogenesis is a key process in both cancer progression and tissue regeneration, feline VEGF-A is studied in veterinary oncology, vascular biology, and regenerative medicine, contributing to understanding of angiogenic signaling and potential therapeutic targets in cats.
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