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Bovine IL-17F Recombinant Protein
- Catalog Number:
- RP0657B
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Bos taurus (cattle)
- Bovine IL-17F (catalog RP0657B) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~15.9 kDa, 140 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to cattle. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-17F signaling and inflammatory responses (including regulation of cytokine production and neutrophil recruitment); typical experimental uses include cell-culture stimulation and dosing studies, cytokine signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | QKPPRSGDSG LCPTLEDHIV RVDIRIRRRN QGVSFSRNLQ NRSISPWDYN ITRDANRFPS EIAEAQCRHM GCINAEGQED RTLNSVPIQQ EFLVLRRKQN GCPGLFQLEK VLVTVGCTCV TPMVRHLHDP MADQVADQLS (140) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 15.9 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Bovine IL-17F (Interleukin-17F) is a pro-inflammatory cytokine belonging to the IL-17 family that contributes to host defense and inflammatory responses in cattle (Bos taurus). IL-17F is produced primarily by Th17 CD4⁺ T cells, as well as by γδ T cells-which are abundant in ruminants-and other innate lymphoid cell populations in response to microbial infection and inflammatory stimulation. It signals through the IL-17 receptor complex (IL-17RA/IL-17RC) to induce expression of pro-inflammatory cytokines, chemokines such as CXCL8, and antimicrobial peptides, thereby promoting neutrophil recruitment and enhancing mucosal barrier immunity in respiratory, gastrointestinal, and mammary tissues. In healthy cattle, basal IL-17F expression is generally low but increases during bacterial and fungal infections, mastitis, respiratory disease, enteric infection, and parasitic challenges. IL-17F often acts in concert with IL-17A to amplify neutrophilic inflammation and mucosal defense. In veterinary and agricultural research, bovine IL-17F serves as a biomarker of Th17-mediated immune activation and is studied in the context of vaccine responses, host-pathogen interactions, and inflammatory disease mechanisms affecting cattle health and productivity.
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