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Canine IL-13 Recombinant Protein
- Catalog Number:
- RP0737D
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Canis lupus familiaris (dog) [Gln78/79Deletion]
- Canine IL-13 (catalog RP0737D) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~12.3 kDa, 112 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to dog. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-13 signaling and type 2 immune responses (including regulation of inflammation, macrophage polarization, and cytokine production); typical experimental uses include cell-culture stimulation and dosing studies, signaling and gene-expression assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | SPSPVTPSPT LKELIEELVN ITQNQASLCN GSMVWSVNLT AGMYCAALES LINVSDCSAI QRTQRMLKAL CSQKPAAGIS SERSRDTKIE VIQLVKNLLT YVRGVYRHGN FR (112) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 12.3 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Canine Interleukin-13 (IL-13) is a Th2-associated cytokine produced primarily by activated CD4⁺ T helper 2 (Th2) cells and other type 2 immune cells in dogs (Canis lupus familiaris), where it plays a central role in allergic inflammation, mucosal immunity, and tissue remodeling. IL-13 signals through receptor complexes composed of IL-13Rα1 and IL-4Rα, activating JAK/STAT6 pathways that promote alternative macrophage activation, IgE-associated immune responses, mucus production, and modulation of pro-inflammatory cytokine signaling. In canine health, IL-13 is particularly relevant in allergic and atopic conditions such as atopic dermatitis, food allergies, eosinophilic airway disease, and certain forms of inflammatory bowel disease, where elevated Th2 cytokine activity contributes to pruritus, eosinophilic infiltration, and chronic tissue inflammation. IL-13 also influences immune responses during parasitic infections by supporting type 2 immunity and tissue repair. Dysregulated IL-13 expression may contribute to chronic allergic inflammation or fibrosis. As a biomarker of Th2 polarization, canine IL-13 is important in studies of allergic disease pathogenesis, vaccine responses, and immune modulation. In translational research, dogs serve as valuable spontaneous models for human atopic dermatitis and allergic airway disease, and characterization of canine IL-13 supports comparative investigations into type 2-mediated inflammation and development of targeted anti-cytokine therapies relevant to both veterinary and human medicine.
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