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Human VEGF-D Recombinant Protein
- Catalog Number:
- RP0756H
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Gorilla gorilla gorilla (western lowland gorilla), Homo sapiens (human), Nomascus leucogenys (northern white-cheeked gibbon), Pan paniscus (pygmy chimpanzee), Pan troglodytes (chimpanzee), Piliocolobus tephrosceles (Ugandan red Colobus), Pongo abelii (Sumatran orangutan), Rhinopithecus roxellana (golden snub-nosed monkey)
- Human VEGF-D (FIGF) (catalog RP0756H) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~13.1 kDa, 117 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to human, orangutan, gorilla, chimpanzee, gibbon, colobus monkey, and snub-nosed monkey. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study VEGF-D/FIGF signaling and lymphangiogenesis (including lymphatic endothelial-cell growth and vascular development); typical experimental uses include cell-culture stimulation and dosing studies, proliferation and migration assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | FAATFYDIET LKVIDEEWQR TQCSPRETCV EVASELGKST NTFFKPPCVN VFRCGGCCNE ESLICMNTST SYISKQLFEI SVPLTSVPEL VPVKVANHTG CKCLPTAPRH PYSIIRR (117) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 13.1 kda |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Human Vascular Endothelial Growth Factor D (VEGF-D) is a member of the vascular endothelial growth factor (VEGF) family, which includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, and placental growth factor (PlGF)-key regulators of angiogenesis and lymphangiogenesis. In humans, VEGF-D is produced by a variety of cell types including fibroblasts, macrophages, epithelial cells, and smooth muscle cells, particularly during development, inflammation, and tissue remodeling. VEGF-D is synthesized as a secreted precursor protein that undergoes proteolytic processing to generate a mature active form capable of binding primarily to VEGF receptor-3 (VEGFR-3/Flt-4) and also VEGF receptor-2 (VEGFR-2/KDR) on endothelial cells. Activation of these receptors stimulates intracellular signaling pathways such as MAPK/ERK and PI3K/AKT, promoting lymphatic endothelial cell proliferation, migration, and formation of lymphatic vessels, while also contributing to angiogenesis in certain tissues. In human physiology, VEGF-D plays important roles in lymphatic vessel development, fluid homeostasis, immune cell trafficking, and tissue repair. Dysregulated VEGF-D expression has been associated with tumor lymphangiogenesis and metastasis, as well as cardiovascular and pulmonary diseases, including lymphangioleiomyomatosis (LAM), where elevated circulating VEGF-D levels are used as a clinical diagnostic biomarker. Because of its role in regulating the lymphatic vasculature, human VEGF-D is widely studied in vascular biology, cancer research, and lymphatic disease, contributing to the development of therapeutic strategies targeting VEGF signaling pathways.
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