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Feline CXCL10 (IP-10) Recombinant Protein
- Catalog Number:
- RP0860F
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Acinonyx jubatus (cheetah), Felis catus (domestic cat), Lynx canadensis (Canada lynx), Lynx pardinus (Spanish lynx), Panthera leo (lion), Panthera pardus (leopard), Panthera tigris altaica (Amur tiger), Panthera uncia (snow leopard), Puma concolor (puma)
- Feline CXCL10 (IP-10) (catalog RP0860F) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~8.7 kDa, 77 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to cat, lion, tiger, leopard, snow leopard, puma, cheetah, and lynx. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CXCL10/IP-10 signaling and immune-cell chemotaxis (including recruitment of activated T cells and NK cells); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | IPLSRTPRCT CIKISELSVN LRSLEKLEVI PASHFCPRVE IIATMKKNGE KTCLNPESKT IKNLVKAISK ERSKRSP (77) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 8.7 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Feline CXCL10 (C-X-C motif chemokine ligand 10), also known as IP-10 (Interferon gamma-induced protein 10), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL9 (MIG) and CXCL11 (I-TAC) that regulate T-cell recruitment during antiviral and inflammatory immune responses. In cats (Felis catus), CXCL10 is produced by macrophages, dendritic cells, epithelial cells, endothelial cells, and fibroblasts in response to interferon-γ (IFN-γ), viral infection, or inflammatory cytokines. CXCL10 signals primarily through the chemokine receptor CXCR3, which is expressed on activated T lymphocytes, natural killer (NK) cells, and other immune cells, promoting chemotaxis and activation of these cells at sites of infection or inflammation. In feline health, CXCL10 is involved in immune responses to viral infections such as feline immunodeficiency virus (FIV) and feline leukemia virus (FeLV), where interferon-driven chemokine signaling helps recruit antiviral immune cells to infected tissues. Cats also serve as important comparative animal models for human viral and immune-mediated diseases; for example, FIV infection in cats is widely used as a model for human HIV/AIDS, where CXCL10-mediated recruitment of CXCR3⁺ T cells contributes to immune activation and viral pathogenesis. In addition, feline infectious peritonitis (FIP) caused by feline coronavirus is used as a model for severe immune-mediated viral inflammation, where CXCL10 expression is associated with T-cell infiltration and cytokine-driven pathology, making feline CXCL10 relevant for studies of antiviral immunity, immune dysregulation, and inflammatory disease mechanisms.
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