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Human CXCL10 (IP-10) Recombinant Protein
- Catalog Number:
- RP0861H
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Gorilla gorilla gorilla (western lowland gorilla), Homo sapiens (human), Hylobates moloch (silvery gibbon), Pan paniscus (pygmy chimpanzee), Pan troglodytes (chimpanzee)
- Human CXCL10 (IP-10) (catalog RP0861H) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~8.6 kDa, 77 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to human, gorilla, gibbon, chimpanzee, and bonobo. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CXCL10/IP-10 signaling and immune-cell chemotaxis (including recruitment of activated T cells and NK cells); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK ERSKRSP (77) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 8.6 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Human CXCL10 (C-X-C motif chemokine ligand 10), also known as IP-10 (Interferon gamma-induced protein 10), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL9 (MIG) and CXCL11 (I-TAC) that regulate T-cell recruitment during antiviral and inflammatory immune responses. In humans (Homo sapiens), CXCL10 is produced by macrophages, dendritic cells, epithelial cells, endothelial cells, fibroblasts, and various tissue cells in response to interferon-γ (IFN-γ), viral infection, or inflammatory cytokines. CXCL10 signals primarily through the chemokine receptor CXCR3, which is expressed on activated T lymphocytes, natural killer (NK) cells, and other immune cells, promoting chemotaxis and activation of these cells at sites of infection or inflammation. CXCL10 plays a critical role in antiviral immunity and Th1-type immune responses, particularly in infections such as hepatitis C virus (HCV) and SARS-CoV-2, where elevated CXCL10 levels are associated with immune cell recruitment to infected tissues and inflammatory disease severity. Because dysregulated CXCL10 signaling has been linked to chronic inflammatory diseases, autoimmune disorders, and cancer-associated inflammation, human CXCL10 is widely studied in immunology, infectious disease research, and therapeutic development as both a biomarker of immune activation and a potential target for modulating inflammatory responses.
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