Human CXCL9 (MIG) Recombinant Protein

Catalog Number:: RP0864H
Availability:: In stock
Application:: Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
100% Homology:: Homo sapiens (human), Pan paniscus (pygmy chimpanzee), Pan troglodytes (chimpanzee)

Human CXCL9 (MIG) (catalog RP0864H) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~11.7 kDa, 103 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to human, chimpanzee, and bonobo. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CXCL9/MIG signaling and immune-cell chemotaxis (including recruitment of activated T cells); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.

Amino Acid Sequence	TPVVRKGRCS CISTNQGTIH LQSLKDLKQF APSPSCEKIE IIATLKNGVQ TCLNPDSADV KELIKKWEKQ VSQKKKQKNG KKHQKKKVLK VRKSQRSRQK KTT (103)
Endotoxin	Naturally endotoxin-free

Storage Conditions	-20°C
Molecular Weight	11.7 kDa
Purity	>98% as visualized by SDS-PAGE analysis.
Country Of Origin	USA

Cynomolgus Monkey (Macaca fascicularis) CXCL9 (C-X-C motif chemokine ligand 9), also known as MIG (monokine induced by interferon-γ), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL10 (IP-10) and CXCL11 (I-TAC) that regulate T-cell recruitment during interferon-driven immune responses. In cynomolgus monkeys, CXCL9 is produced by macrophages, dendritic cells, endothelial cells, and epithelial cells in response to interferon-γ (IFN-γ) and inflammatory stimuli during infection or immune activation. CXCL9 signals primarily through the chemokine receptor CXCR3, which is expressed on activated T lymphocytes, natural killer (NK) cells, and other immune cells, promoting chemotaxis and accumulation of these cells at sites of infection or inflammation. Because cynomolgus monkeys share close genetic, immunological, and physiological similarities with humans, they are widely used as preclinical animal models for infectious diseases and immunological research. In these models, CXCL9 is part of the interferon-regulated chemokine network involved in antiviral immunity, including studies of SARS-CoV-2, dengue virus, and other viral infections, where CXCL9 contributes to CXCR3⁺ T-cell recruitment to infected tissues and regulation of inflammatory responses, making it an important marker of Th1-type immune activation in translational biomedical research.

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