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Guinea Pig IL-15 Recombinant Protein
- Catalog Number:
- RP0872GP
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Cavia porcellus (domestic guinea pig)
- Guinea Pig IL-15 (catalog RP0872GP) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~13.1 kDa, 114 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to guinea pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-15 signaling and immune-cell biology (including NK-cell and T-cell proliferation, survival, and activation); typical experimental uses include cell-culture stimulation and dosing studies, proliferation and activation assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | SWHDVIYDLK RIENLIQSIH IDATLYTESD VHPNCKITAM KCFLLELRVI LHESRNEDIH ETITNLIILA NSSLNSNGNV TESGCKECEE LEEKSIAEFL QSFVHIVQMF INTS (114) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 13.1 kda |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Guinea Pig Interleukin-15 (IL-15) is a cytokine that plays an important role in regulating innate and adaptive immune responses in guinea pigs (Cavia porcellus). IL-15 is produced by a variety of cell types, including monocytes, macrophages, dendritic cells, and epithelial cells, in response to infection or inflammatory stimuli. Guinea pig IL-15 signals through a receptor complex composed of IL-15Rα together with the shared IL-2/15Rβ (CD122) and common γ chain (γc), activating intracellular signaling pathways such as JAK-STAT that promote lymphocyte proliferation, survival, and activation. In guinea pigs, IL-15 is particularly important for the development, maintenance, and activation of natural killer (NK) cells and memory CD8⁺ T cells, supporting cytotoxic immune responses against infected cells. It also contributes to regulation of mucosal immunity and inflammatory responses during infection. In cell culture, recombinant guinea pig IL-15 is commonly used to stimulate proliferation and survival of NK cells and cytotoxic T lymphocytes, maintain memory CD8⁺ T cell populations, and enhance cytotoxic activity in in vitro immune assays. Guinea pig IL-15 is widely studied in infectious disease and translational research because guinea pigs serve as an important model for diseases such as tuberculosis, where IL-15-mediated activation of cytotoxic lymphocytes helps researchers investigate cellular immunity and evaluate vaccines and immunotherapies relevant to human disease.
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