Swine CCL28 (C-C motif chemokine ligand 28, also known as MEC – mucosae-associated epithelial chemokine) is a mucosal chemokine that plays an important role in immune cell trafficking and mucosal immune defense in pigs (Sus scrofa domesticus). CCL28 primarily signals through the CCR10 receptor and, to a lesser extent, CCR3, promoting chemotaxis of IgA-secreting plasma cells, memory T cells, and certain dendritic cell populations to mucosal tissues. In pigs, CCL28 is predominantly produced by epithelial cells of mucosal surfaces, including the intestinal tract, respiratory epithelium, salivary glands, and mammary glands, where it supports recruitment of IgA-producing plasma cells and maintenance of secretory IgA–mediated immunity. This chemokine is particularly important in the gut-associated lymphoid tissue (GALT) and other mucosal immune compartments, helping establish protective immune responses against enteric and respiratory pathogens. In swine health, CCL28-mediated immune cell trafficking contributes to mucosal defense against infections such as porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and enterotoxigenic Escherichia coli, as well as respiratory pathogens including swine influenza virus. Because pigs are widely used as large-animal models for human mucosal immunity and gastrointestinal physiology, characterization of swine CCL28 supports research into mucosal antibody responses, immune cell homing mechanisms, and development of mucosal vaccines relevant to both veterinary medicine and human health.