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Swine CCL28 Recombinant Protein
- Catalog Number:
- RP0876S
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Phacochoerus africanus (Common warthog), Sus scrofa (pig)
- Swine CCL28 (catalog RP0876S) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~12.2 kDa, 105 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig and warthog. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CCL28 signaling and mucosal immunity (including recruitment of IgA-secreting plasma cells and lymphocyte trafficking); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | ILPIASSCCT EVSHHISRRL LERVNTCRLQ RADGDCDLAA VILHVKRRRI CVSPHNHLIK QWMKEQAAKK DAKGNICHKK KHHSKRNSKG AHQEKHETHG HKTPY (105) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 12.2 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Swine CCL28 (C-C motif chemokine ligand 28, also known as MEC - mucosae-associated epithelial chemokine) is a mucosal chemokine that plays an important role in immune cell trafficking and mucosal immune defense in pigs (Sus scrofa domesticus). CCL28 primarily signals through the CCR10 receptor and, to a lesser extent, CCR3, promoting chemotaxis of IgA-secreting plasma cells, memory T cells, and certain dendritic cell populations to mucosal tissues. In pigs, CCL28 is predominantly produced by epithelial cells of mucosal surfaces, including the intestinal tract, respiratory epithelium, salivary glands, and mammary glands, where it supports recruitment of IgA-producing plasma cells and maintenance of secretory IgA-mediated immunity. This chemokine is particularly important in the gut-associated lymphoid tissue (GALT) and other mucosal immune compartments, helping establish protective immune responses against enteric and respiratory pathogens. In swine health, CCL28-mediated immune cell trafficking contributes to mucosal defense against infections such as porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and enterotoxigenic Escherichia coli, as well as respiratory pathogens including swine influenza virus. Because pigs are widely used as large-animal models for human mucosal immunity and gastrointestinal physiology, characterization of swine CCL28 supports research into mucosal antibody responses, immune cell homing mechanisms, and development of mucosal vaccines relevant to both veterinary medicine and human health.
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