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Swine IL-12/IL-23 p40 Recombinant Protein
- Catalog Number:
- RP0879S
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Sus scrofa (pig)
- Swine IL-12 p40 (catalog RP0879S) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~34.3 kDa, 302 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to pig. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study IL-12 signaling and immune responses (including regulation of Th1 responses and IFN-γ production); typical experimental uses include cell-culture stimulation and dosing studies, cytokine signaling assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | IWELEKNVYV VELDWYPNAP GEMVVLTCNT PEEDGITWTS DQSSEVLGTG KTLTIHVKEF GDAGQYTCRK GGAVLSQSLL LLHKKEDGIW STDILKDQKE PKNKSFLKCE AKNYSGRFTC WWLTAISTDL KFSVKSSRGS TDPRGVTCGT ATLSEDLGEY KKYRVECQEG SACPAAEESL PIEVVLEAVH KLKYENYTSS FFIRDIIKPD PPKNLQLNPL KNSRHVEISW EYPDTWSTPH SYFSLMFGVQ VQGKNKREKK DKLFTDQISA KVTCHKDANI RVQARDRYYS SSWSEWASVS CN (302) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 34.3 kda |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Swine Interleukin-12/Interleukin-23 p40 (IL-12/IL-23 p40) is a cytokine subunit that plays an important role in regulating immune responses in pigs (Sus scrofa). The p40 subunit is shared by two heterodimeric cytokines, IL-12 and IL-23, where it pairs with the p35 subunit to form IL-12 and with the p19 subunit to form IL-23. These cytokines are produced primarily by activated antigen-presenting cells, including macrophages and dendritic cells, in response to microbial infection or inflammatory stimuli. Swine IL-12/IL-23 p40 contributes to activation of natural killer (NK) cells and differentiation of T helper cells toward Th1-type immune responses, promoting production of interferon-γ (IFN-γ) and enhancing cell-mediated immunity against intracellular pathogens. Through IL-23 signaling, the p40 subunit also supports maintenance and expansion of Th17 cells involved in inflammatory and host defense pathways. In pigs, IL-12/IL-23 p40 participates in immune responses against viral, bacterial, and parasitic infections and is studied in the context of important swine diseases such as porcine reproductive and respiratory syndrome virus (PRRSV), African swine fever virus (ASFV), and Salmonella infections. Due to its role in regulating cellular immunity, swine IL-12/IL-23 p40 is widely studied in veterinary immunology and translational research, including investigations of host-pathogen interactions, vaccine development, and immune responses relevant to both swine health and comparative biomedical research.
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