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Mouse TWEAK (TNFSF12) Recombinant Protein
- Catalog Number:
- RP0898M
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Mus musculus (house mouse)
- Mouse TWEAK (TNFSF12) (catalog RP0898M) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~17.2 kDa, 156 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to house mouse. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study TWEAK/TNFSF12 signaling and immune and tissue biology (including inflammation, apoptosis, and tissue remodeling); typical experimental uses include cell-culture stimulation and dosing studies, signaling and functional assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | SAPKGRKARP RRAIAAHYEV HPRPGQDGAQ AGVDGTVSGW EETKINSSSP LRYDRQIGEF TVIRAGLYYL YCQVHFDEGK AVYLKLDLLV NGVLALRCLE EFSATAASSP GPQLRLCQVS GLLPLRPGSS LRIRTLPWAH LKAAPFLTYF GLFQVH (156) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 17.2 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Mouse TWEAK (TNF-like Weak Inducer of Apoptosis, also known as TNFSF12) is a cytokine belonging to the tumor necrosis factor (TNF) superfamily, which includes related ligands such as TNF-α, Fas ligand (FasL), CD40 ligand (CD40L), TRAIL, and RANKL that regulate immune signaling, apoptosis, and tissue remodeling. In mice (Mus musculus), TWEAK is produced primarily by immune cells such as macrophages, monocytes, dendritic cells, and T lymphocytes, and can also be expressed by endothelial cells and other tissue cells during inflammation or tissue injury. TWEAK exerts its biological effects mainly through binding to its receptor Fn14 (fibroblast growth factor-inducible 14, TNFRSF12A), activating intracellular signaling pathways including NF-κB, MAPK, and other inflammatory signaling cascades that regulate cell survival, proliferation, apoptosis, and cytokine production. In mice, the TWEAK-Fn14 signaling axis has been extensively studied in models of tissue injury, inflammatory disease, and cancer, where it contributes to immune cell activation, tissue remodeling, angiogenesis, and regeneration. Murine studies have also shown that TWEAK signaling plays important roles in muscle regeneration, kidney injury, liver inflammation, and autoimmune disease models, highlighting its involvement in both inflammatory pathology and tissue repair mechanisms. Because mice are widely used as experimental models in immunology and disease research, characterization of mouse TWEAK has been critical for understanding TNF superfamily signaling pathways and their roles in inflammation, tissue damage, and regenerative responses.
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