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Rat CXCL10 (IP-10) Recombinant Protein
- Catalog Number:
- RP0899R
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Rattus norvegicus (Norway rat), Rattus rattus (black rat)
- Rat CXCL10 (IP-10) (catalog RP0899R) is a yeast-derived chemokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~8.7 kDa, 77 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to rat and black rat. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study CXCL10/IP-10 signaling and immune-cell chemotaxis (including recruitment of activated T cells and NK cells); typical experimental uses include cell-culture stimulation and migration assays, chemotaxis and signaling studies, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | IPLARTVRCT CIDFHEQPLR PRAIGKLEII PASLSCPHVE IIATMKKNNE KRCLNPESEA IKSLLKAVSQ RRSKRAP (77) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 8.7 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Rat CXCL10 (C-X-C motif chemokine ligand 10), also known as IP-10 (Interferon gamma-induced protein 10), is a proinflammatory chemokine belonging to the CXC chemokine family, which also includes CXCL9 (MIG) and CXCL11 (I-TAC) that regulate T-cell recruitment during antiviral and inflammatory immune responses. In rats (Rattus norvegicus), CXCL10 is produced by macrophages, dendritic cells, epithelial cells, endothelial cells, and fibroblasts in response to interferon-γ (IFN-γ), viral infection, or inflammatory cytokines. CXCL10 signals primarily through the chemokine receptor CXCR3, which is expressed on activated T lymphocytes, natural killer (NK) cells, and other immune cells, promoting chemotaxis and activation of these cells at sites of infection or inflammation. In rat models, CXCL10 plays an important role in Th1-mediated immune responses and inflammatory disease processes, particularly in the central nervous system and cardiovascular system. Rats are widely used as animal models for autoimmune and inflammatory diseases, including experimental autoimmune encephalomyelitis (EAE), a model for human multiple sclerosis, where CXCL10 contributes to recruitment of CXCR3⁺ T cells into the central nervous system and development of neuroinflammation and demyelination. These studies make rat CXCL10 an important molecule for understanding chemokine-driven immune cell trafficking and mechanisms of immune-mediated pathology.
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