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Equine BAFF Recombinant Protein
- Catalog Number:
- RP0904E
- Availability:
- In stock
- Application:
- Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control
- 100% Homology:
- Equus asinus (ass), Equus caballus (horse), Equus przewalskii (Przewalski's horse)
- Equine BAFF (TNFSF13B) (catalog RP0904E) is a yeast-derived cytokine supplied lyophilized without carrier protein in 10% trehalose; it has no affinity tags and is naturally endotoxin-free, and should be reconstituted in sterile PBS that contains at least 0.1% carrier protein. The protein is ~17.0 kDa, 152 amino acids long (full sequence provided), and >98% pure by SDS-PAGE, with 100% amino-acid homology to horse, Przewalski's horse, and donkey. Store at -20°C (stable up to twelve months from date of receipt; working aliquots with carrier protein stable ~3 months) and avoid repeated freeze/thaw cycles. Product origin is the USA. It is commonly used to study BAFF/TNFSF13B signaling and B-cell biology (including survival, maturation, and antibody production); typical experimental uses include cell-culture stimulation and dosing studies, proliferation and survival assays, ELISA and neutralization assays, flow-cytometry and Western blot controls, and antibody generation/validation. Kingfisher Biotech products are supplied for research applications and are not intended for medicinal, diagnostic, or therapeutic use.
| Amino Acid Sequence | AAQDSEEAVT QDCLQLIADS DTPTIRKGAY TFVPWLLSFK RGKALEEKEN KILVKETGYF FIYGQVLYTD NTFAMGHLIQ RKKVHVFGDE LSLVTLFRCI QNMPETLPNN SCYSAGIAKL EEGDELQLAI PREDAKISRD GDGTFFGALK LL (152) |
| Endotoxin | Naturally endotoxin-free |
| Storage Conditions | -20°C |
| Molecular Weight | 17.0 kDa |
| Purity | >98% as visualized by SDS-PAGE analysis. |
| Country Of Origin | USA |
- Equine BAFF (B cell-Activating Factor), also known as BLyS or TNFSF13B, is a member of the tumor necrosis factor (TNF) superfamily and plays a central role in B cell development, survival, and regulation of humoral immunity in horses (Equus caballus). BAFF is produced primarily by monocytes, macrophages, dendritic cells, neutrophils, and certain stromal cells, and it signals through the receptors BAFF-R (TNFRSF13C), TACI (TNFRSF13B), and BCMA (TNFRSF17) to promote peripheral B cell maturation, immunoglobulin class switching, and maintenance of long-lived plasma cells. In healthy horses, BAFF supports normal antibody production and immune homeostasis in systemic and mucosal tissues, including the respiratory and gastrointestinal tracts. Dysregulated or elevated BAFF expression may contribute to chronic inflammation, autoantibody production, and B cell proliferation in conditions such as equine recurrent uveitis, equine asthma, inflammatory bowel disease-like syndromes, and lymphoid malignancies. In veterinary and comparative medicine research, equine BAFF is of particular interest in studies of vaccine-induced antibody responses, mucosal immunity, autoimmune disease models, and comparative B cell biology. Characterizing BAFF signaling in horses provides valuable insight into regulation of humoral immunity and potential therapeutic strategies targeting B cell-mediated disease in equine and translational research contexts.
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